"Three parents" baby technical details released: mitochondrial genetic disease patients to give birth to healthy offspring.

The technical details of the world's first nuclear transplant "three parents" baby were officially announced on the 3rd.
say the baby is in good health, created new hope for healthy offspring in families plagued by mitochondrial genetic disease.
Jin, of the New Hope Center for Reproductive Medicine in the United States, and others published an eight-page paper in the journal Reproductive Biomedical Online on the same day, introducing some details about the first nuclear transplant "three parents" baby.
Everyone inherits three genetic material from their parents: the nucleocarbon DNA (deoxybonucleic acid) of the father's sperm, the nucleobon DNA of the mother's egg, and the mitochondrial DNA of the mother's egg independent of the nuclea.
mother-of-three, whose mitochondria carry the gene for subacute necrotic encephalopathy, miscarried four times and gave birth to two children, was born on April 6, 2016 in New York, U.S., the paper said.
to help the woman, Zhang Jin's team used "three parents" technology to remove the nucle nucleations of healthy cells in the problem eggs and put them into the donated eggs.
nucleosome of the donor egg has been removed in advance, but the cytotyte in which the mitochondrial is located remains, so that the baby has the mitochondrial genetic material of the donor woman in addition to the gene of the parents.
the baby boy was born after 37 weeks of pregnancy, the proportion of mitochondrial variation in the tissue cells varied from 2.36 percent to 9.23 percent.
generally believe that mitochondrial disease needs to mutate by more than 20%.
"three-parent" baby technology has been released in the UK, but the US and other countries still ban it because of ethical disputes. Zhang Jin,
, said they completed steps in New York, including ovarian stimulation, egg collection, mitochondrial replacement surgery and in vitro fertilization, and the embryos were implanted in patients in Mexico without limiting the "three parents" technique.
to "stitch up" the nucleus and cytocytes, they have developed electro-fusion technology, which is safer and more psychologically acceptable to patients than previously used virus fusion techniques.
For the first time today, we have been able to modify an egg with abnormal mitochondrials to contain normal mitochondrials that are largely normal from healthy egg donors," Bart Fosser, editor-in-chief of Reproductive Biomedical Online, said in a statement.
But professor Robin Lovell-Bage, of the Francis Crick Institute in the UK, said that while the first "three-parent" baby was in good health, "from the paper, Zhang Jin and his colleagues took a lot of risks in many ways, and the result was largely luck".
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