Through the event of "Yinqiao antidote tablet", which Chinese patent medicines in the market contain paracetamol?

Recently, longshunrong pharmaceutical factory (hereinafter referred to as longshunrong pharmaceutical factory) of Tianjin Zhongxin Pharmaceutical Group Co., Ltd produced and sold the antidote tablet of Yinqiao in Hong Kong, which was publicly rectified by CFDA due to the detection of paracetamol (paracetamol) containing ingredients For a while, the enterprise was pushed to the commanding height of public opinion Affected by this incident, "which Chinese patent medicines in the market contain paracetamol" quickly entered the industry hot search list According to the statistics of the Chinese patent medicines approved by the State Food and Drug Administration (the Ministry of health in the early stage) included in the prescription database of Yaozhi Chinese patent medicines, there are 44 kinds of Chinese patent medicines already on the market that contain western medicine component paracetamol, and most of them are cold drugs (as shown in Table 1) Table 1: paracetamol, 44 kinds of Chinese patent medicine containing paracetamol, is a kind of antipyretic and analgesic drug familiar to the common people It is applicable to relieve mild to moderate pain, such as fever, headache, arthralgia, neuralgia caused by cold, etc The commonly used oral dose for adults is 300mg-600mg once, and the daily dose should not exceed 2000mg That's the problem First, paracetamol is a kind of antipyretic and analgesic drug, and it's also the best one among acetanilide drugs, so it's not wrong to use it as a cold medicine Second, the problem "Yinqiao detoxification tablet" (batch No.: mh-151) produced by longshunrong pharmaceutical factory only contains trace paracetamol (detection amount is 0.083mg / tablet), which does not exceed the national safe drug dosage 。 Why can the 44 Chinese patent medicines listed in Table 1 be added with paracetamol, while the "Yinqiao antidote tablet" produced by longshunrong pharmaceutical factory is stopped for rectification when it is detected with trace paracetamol? The main reason is that the production operation of "Yinqiao antidote tablet" with the batch number of mh-151 in longshunrong pharmaceutical factory does not conform to the national GMP (drug production quality management specification), its Yinqiao antidote tablet and refined Yinqiao antidote tablet share the tablet press, and the approved prescription of refined Yinqiao antidote tablet contains paracetamol 60mg / tablet, resulting in cross contamination of products due to incomplete site clearance In principle, some Western ingredients can be added to the Chinese patent medicine, but the ingredients of the medicine to be produced and marketed must be consistent with the prescription ingredients approved by the State Food and drug administration, otherwise, it will only repeat the mistakes of longshunrong pharmaceutical factory! Data source: Pharmaceutical manual database: http://db.yaozh.com/instrument; Chinese patent prescription database: http://db.yaozh.com/chufang original statement: the intellectual property of this article belongs to pharmaceutical intelligent network If you need to reprint, please indicate the source and the link of this article.