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Thyroid cancer is diagnosed at a younger age than most other malignant tumor patients in the population, and the incidence is higher in women than in men; the only identifiable modifiable risk factor for thyroid cancer is individual exposure to ionizing radiation and obesity in childhood, said researcher Professor Tone Bjorge.
so far, researchers have not identified or rarely found life risk factors in the womb or early stages of thyroid cancer.
the researchers, who looked at four Nordic countries (Denmark, Finland, Norway and Sweden) conducted a nest-based case-control study of 2,437 patients aged 0-48 and 24,362 matching control individuals between 1967 and 2015.
Researchers found a clear association between maternal benign thyroid diseases such as hypothyroidism, hyperthyroidism, goiter and benign goiter tumors or the risk of thyroid cancer in offspring; Bjorge, a
researcher, said the study supports a link between intrateral exposure and an increased risk of thyroid cancer in later life in offspring, and later researchers will continue to delve deeper into the molecular mechanisms that explain the increased risk of late thyroid in early exposure.
original source: Cari M Kitahara et al. Maternal health, in-utero, and perinatal exposures and risk of thyroid cancer in offspring: a Nordic population-based nested case-control study, The Lancet Diabetes & Endocrinology (2020). DOI:10.1016/S2213-8587(20)30399-5。