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In observational studies in the elderly, low serum TSH levels are associated with an increased risk of cognitive impairment, but the underlying mechanism is not yet clear
.
Recently, a research article was published in Thyroid, an authoritative journal in the field of thyroid diseases.
Researchers used prospective data from the study of elderly people over 85 years old in Newcastle to explore the relationship between changes in thyroid status and cognitive impairment in the elderly
.
The researchers evaluated the health status and thyroid function of the 85-year-old population
Researchers performed comprehensive multi-dimensional health examinations and repeated thyroid function measurements on 642 participants with normal free thyroid hormones and TSH levels between 0.
1-10mU/L, and obtained complete data
.
Researchers used Mini Mental State Examination (MMSE) and a series of cognitive drug research tests to assess cognitive ability, and used linear mixed, logistic regression and Cox proportional hazard models to assess cognitive ability and basic serum TSH, free T4 and free Correlation between T3 level and 3-year change value
The relationship between thyroid function and cognitive ability
During the 3-year period, the decrease in serum TSH was associated with the decrease in free T4 and free T3, and was associated with an increased risk of cognitive impairment during the 5-year period [OR=1.
77 (95%CI: 1.
19-2.
61); p=0.
004)
.
The more the MMSE score decreases, the greater the decrease in TSH (p<0.
It can be seen that, contrary to physiological expectations, in 85-year-old people, serum TSH declines and free thyroid hormones decrease over time
.
A decrease in serum TSH over time indicates a decline in cognitive ability in later life
Contrary to physiological expectations, in 85-year-olds, serum TSH decreases and free thyroid hormones decrease over time
Original source:
Earn H Gan,et al.
Changes in serum thyroid function predict cognitive decline in the very old: longitudinal findings from the Newcastle 85+ study in this message
