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Subclinical hypothyroidism (SCH) is diagnosed according to the serum thyroid hormone (TSH) reference range, which is influenced by many factors.
, a study published in Thyroid, an authoritative journal in the field of thyroid disease, looked at 78,470 participants in china's National Cross-Sectional Study (TIDE).
study population is a participant in the TIDE program, and the control population is part of the overall population defined in the National Institute of Clinical Biochemistry (NACB) guidelines.
the researchers measured the concentration of thyroid hormones, TSH, thyroid antibodies and urine iodine concentration (UIC) in the subjects' serum.
average serum TSH geometry (2.5th-97.5th) for the controlled population (defined by NACB) and the total population (2.28 mIU/L (0.74-7.04 mIU/L) and 2.34 mIU/L (0.61-8.33 mIU/L), respectively.
, the increase in UIC was significantly associated with increases of 50 and 97.5 per cent of TSH and a decrease of 2.5 per cent in the control population.
TSH for women is significantly higher than for men (2.41 mIU/L and 2.16 mIU/L, P?lt;0.001).
age was significantly associated with an increase in the 97.5th decimal place of TSH.
10 years, TSH's 97.5 percent score increases by 0.534 mIU/L.
in the TIDE study, there were significant differences in SCH prevalence diagnosed based on the recommended range of kits (Roche 0.27-4.2 mIU/L) and the NACB standard range (0.74-7.04 mIU/L) (Roche 13.61% vs. TIDE 3.00%, P?lt;0.05).
However, there was no significant difference in future CVD risk (cardiovascular disease, as reflected in framingham risk score) in the two groups of subjects with thyroxine of 0.27-4.2 mIU/L and 4.2-7.04 mIU/L.
that the concentration of serum TSH increased significantly with the increase of iodine intake.
therefore, iodine intake must be taken into account when establishing the TSH reference range.
to avoid overdiagnosis and overtreathing of SCH, separate serum TSH reference ranges should be used in different regions.
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