Thyroid: Increased A-FABP levels in people with normal thyroid function are associated with reduced thyroid hormone sensitivity

Serum fat cell fatty acid binding protein (A-FABP) and thyroid hormone are closely related to metabolic abnormalitiesHowever, the relationship between them is still unknownIn a recent study published in the authoritative journal Thyroid, the field of thyroid disease, researchers investigated the association between serum A-FABP levels and individual and compound indicators of thyroid functionthe study included 1,057 community thyroid function participants (age range: 27-81 years old) in Shanghai, of whom 601 were womenThe researchers measured serum free triamcinolone (FT3), free thyroxine (FT4) and thyroid stimulating hormone (TSH) using electrochemical luminescence immunoassays, and calculated the thyroid feedback digitization index (TFQI), thyroid-stimulating hormone index (TSHI) and thyroid-troxine-T4 resistance index (TT4RI) to assess sensitivity to thyroid hormonesThe researchers assessed the peripheral sensitivity of thyroid hormones using the FT3 to FT4 ratio (FT3/FT4) and measured serum A-FABP levels using enzymatic immunosorption assaysserum A-FABP water average of 6.41 (95% confidence interval: 6.10-6.74) ng/ml for all subjectsMultiple cardiovascular metabolic risk factors were adjusted in multiple linear regression analysis and multiple Logistic regression analysis (unconventional)In men and women, serum A-FABP levels and FT4 (men: standardized beta-0.150, P-0.001; women: standardized beta-0.218, P-0.001), TFQI (men: standardized beta-0.119, P-0.009; female:standardized beta-0.165, P.001) and TT SHI (men: standardized beta s.108, P-0.017; female: standardized beta-0.114, P-0.005) is positively correlated, and ft3/FT4 is negatively correlated (male: standardized beta-0.122, P-0.008; female: standardized beta-0.129, P-0.001)Serum A-FABP levels are not associated with FT3, TSH or TT4RICompared to TFQI as the first quartile array, for every 10 ng/ml increase in female A-FABP, the ratio of women in the third quartile array of TFQI is 2.213 (P-0.035);it is shown that in people with normal thyroid levels, elevated serum A-FABP levels are associated with decreased sensitivity to thyroid hormones, suggesting that A-FABP may mediate the interaction between adipose tissue and the thyroid system