Thyroid: Patients with Graves disease have an increased remission rate after long-term use of methimazole

Background: Compared with the conventional course of treatment, whether long-term antithyroid drug treatment will increase the remission rate of patients with Graves hyperthyroidism, there are still differences in this aspect of research
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We conducted a prospective, randomized, controlled study to compare the recurrence rate of patients who received a longer period of methimazole treatment and conventional treatment

Methods: 302 untreated patients with Graves hyperthyroidism for the first time were enrolled
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After 18-24 months of methimazole treatment, 258 patients (85.

Results: The long-term medication time of methimazole was 95±22 months, and the routine group medication time was 19±3 months
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During the first 18 months of treatment, 14 patients had skin reactions and 2 patients had elevated liver enzymes

In the routine group, older age, higher triiodothyronine or thyrotropin receptor antibody, lower thyrotropin concentration, or rs1879877 CD28 polymorphism or DQB1-05 HLA polymorphism are all associated with relapse Independently related

Figure 1 Kaplan-Meier curve of the recurrence of Graves' disease after stopping methimazole.
The conventional group received methimazole treatment for 15-24 months, and the long-term group received methimazole treatment for 60-120 months
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Figure 1 Kaplan-Meier curve of the recurrence of Graves' disease after stopping methimazole.
The conventional group received methimazole treatment for 15-24 months, and the long-term group received methimazole treatment for 60-120 months
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Figure 2 The serum FT4, triiodothyronine and thyrotropin concentrations and the termination dose of methimazole in the long-term group of patients observed according to the final remission or final recurrence of hyperthyroidism
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Figure 2 The serum FT4, triiodothyronine and thyrotropin concentrations and the termination dose of methimazole in the long-term group of patients observed according to the final remission or final recurrence of hyperthyroidism
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Conclusion: The low dose of methimazole treatment 60 - 120 months can safely and effectively treat Graves' Disease, which is much higher than the conventional response rate of 18 is - 24 months of treatment
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Low dose of methimazole treatment 60 - 120 months can safely and effectively treat Graves' Disease, which is much higher than the conventional response rate of 18 is - 24 months of treatment
.

Original source

Azizi F, Amouzegar A, Tohidi M, Increased Remission Rates After Long-Term Methimazole Therapy in Patients with Graves' Disease: Results of a Randomized Clinical Trial.

Increased Remission Rates After Long-Term Methimazole Therapy in Patients with Graves' Disease: Results of a Randomized Clinical Trial.
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