echemi logo
Product
  • Product
  • Supplier
  • Inquiry
    Home > Active Ingredient News > Endocrine System > Thyroid: the association between human chorionic gonadotropin, free thyroxine in pregnant women and gestational diabetes

    Thyroid: the association between human chorionic gonadotropin, free thyroxine in pregnant women and gestational diabetes

    • Last Update: 2021-03-23
    • Source: Internet
    • Author: User
    Search more information of high quality chemicals, good prices and reliable suppliers, visit www.echemi.com
    Introduction: A recent study published in the journal Thyroid found that increased hCG in early pregnancy is associated with a decreased risk of GDM.

    Researchers speculate that maternal FT4 may be an important mediator of this association.

    It is currently known that human chorionic gonadotropin (hCG) is a marker of placental function and also has a stimulating effect on the maternal thyroid, and maternal thyroid function is related to the pathophysiology of gestational diabetes (GDM).

    The purpose of this study is to explore whether hCG concentration in early pregnancy is related to GDM and whether it is mediated by maternal thyroid hormone.

    Study description This study included 18,683 pregnant women who attended a tertiary hospital in Shanghai from January 2015 to December 2016.

    According to the guidelines of the American Diabetes Association (ADA), the researchers used 2h75gOGTT to diagnose GDM, and used multivariate logistic or linear regression models to identify its correlation.
    The relationship between maternal age, education level, family history of diabetes, parity, fetal sex, and thyroid The peroxidase antibody (TPOAb) and pre-pregnancy body mass index (BMI) were adjusted.

    According to the results of the study, during the OGTT process, it was found that higher hCG concentration was associated with lower blood glucose, but it had nothing to do with the fasting blood glucose concentration or HbA1c (HbA1c) level detected in early pregnancy.

    In addition, it was found that the hCG level in early pregnancy was negatively correlated with the risk of GDM (p=0.
    027); about 21.
    4% of the correlation between hCG and GDM risk was mediated by changes in the concentration of free thyroxine (FT4) (p< 0.
    05); In the sensitivity analysis that included only TPOAb-positive subjects, hCG was not associated with GDM (p=0.
    452).

    Studies have found that increased hCG in early pregnancy is associated with a decreased risk of GDM.

    Maternal FT4 may be an important mediator of this association.

    Yimaitong compiled and compiled from: Liu Y, Guo F, Maraka S, et al.
    Associations between Human Chorionic Gonadotropin, Maternal Free Thyroxine, and Gestational Diabetes Mellitus.
    Thyroid.
    Thyroid.
    2021.
    DOI: 10.
    1089/thy.
    2020.
    0920.
    This article is an English version of an article which is originally in the Chinese language on echemi.com and is provided for information purposes only. This website makes no representation or warranty of any kind, either expressed or implied, as to the accuracy, completeness ownership or reliability of the article or any translations thereof. If you have any concerns or complaints relating to the article, please send an email, providing a detailed description of the concern or complaint, to service@echemi.com. A staff member will contact you within 5 working days. Once verified, infringing content will be removed immediately.

    Contact Us

    The source of this page with content of products and services is from Internet, which doesn't represent ECHEMI's opinion. If you have any queries, please write to service@echemi.com. It will be replied within 5 days.

    Moreover, if you find any instances of plagiarism from the page, please send email to service@echemi.com with relevant evidence.