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Introduction: A recent study published in the journal Thyroid found that increased hCG in early pregnancy is associated with a decreased risk of GDM.
Researchers speculate that maternal FT4 may be an important mediator of this association.
It is currently known that human chorionic gonadotropin (hCG) is a marker of placental function and also has a stimulating effect on the maternal thyroid, and maternal thyroid function is related to the pathophysiology of gestational diabetes (GDM).
The purpose of this study is to explore whether hCG concentration in early pregnancy is related to GDM and whether it is mediated by maternal thyroid hormone.
Study description This study included 18,683 pregnant women who attended a tertiary hospital in Shanghai from January 2015 to December 2016.
According to the guidelines of the American Diabetes Association (ADA), the researchers used 2h75gOGTT to diagnose GDM, and used multivariate logistic or linear regression models to identify its correlation.
The relationship between maternal age, education level, family history of diabetes, parity, fetal sex, and thyroid The peroxidase antibody (TPOAb) and pre-pregnancy body mass index (BMI) were adjusted.
According to the results of the study, during the OGTT process, it was found that higher hCG concentration was associated with lower blood glucose, but it had nothing to do with the fasting blood glucose concentration or HbA1c (HbA1c) level detected in early pregnancy.
In addition, it was found that the hCG level in early pregnancy was negatively correlated with the risk of GDM (p=0.
027); about 21.
4% of the correlation between hCG and GDM risk was mediated by changes in the concentration of free thyroxine (FT4) (p< 0.
05); In the sensitivity analysis that included only TPOAb-positive subjects, hCG was not associated with GDM (p=0.
452).
Studies have found that increased hCG in early pregnancy is associated with a decreased risk of GDM.
Maternal FT4 may be an important mediator of this association.
Yimaitong compiled and compiled from: Liu Y, Guo F, Maraka S, et al.
Associations between Human Chorionic Gonadotropin, Maternal Free Thyroxine, and Gestational Diabetes Mellitus.
Thyroid.
Thyroid.
2021.
DOI: 10.
1089/thy.
2020.
0920.
Researchers speculate that maternal FT4 may be an important mediator of this association.
It is currently known that human chorionic gonadotropin (hCG) is a marker of placental function and also has a stimulating effect on the maternal thyroid, and maternal thyroid function is related to the pathophysiology of gestational diabetes (GDM).
The purpose of this study is to explore whether hCG concentration in early pregnancy is related to GDM and whether it is mediated by maternal thyroid hormone.
Study description This study included 18,683 pregnant women who attended a tertiary hospital in Shanghai from January 2015 to December 2016.
According to the guidelines of the American Diabetes Association (ADA), the researchers used 2h75gOGTT to diagnose GDM, and used multivariate logistic or linear regression models to identify its correlation.
The relationship between maternal age, education level, family history of diabetes, parity, fetal sex, and thyroid The peroxidase antibody (TPOAb) and pre-pregnancy body mass index (BMI) were adjusted.
According to the results of the study, during the OGTT process, it was found that higher hCG concentration was associated with lower blood glucose, but it had nothing to do with the fasting blood glucose concentration or HbA1c (HbA1c) level detected in early pregnancy.
In addition, it was found that the hCG level in early pregnancy was negatively correlated with the risk of GDM (p=0.
027); about 21.
4% of the correlation between hCG and GDM risk was mediated by changes in the concentration of free thyroxine (FT4) (p< 0.
05); In the sensitivity analysis that included only TPOAb-positive subjects, hCG was not associated with GDM (p=0.
452).
Studies have found that increased hCG in early pregnancy is associated with a decreased risk of GDM.
Maternal FT4 may be an important mediator of this association.
Yimaitong compiled and compiled from: Liu Y, Guo F, Maraka S, et al.
Associations between Human Chorionic Gonadotropin, Maternal Free Thyroxine, and Gestational Diabetes Mellitus.
Thyroid.
Thyroid.
2021.
DOI: 10.
1089/thy.
2020.
0920.