Thyroid: U-type association between urine iodine concentration and metabolic disorder prevalence

Iodine is important in thyroid function and human metabolismStudies have explored the effects of iodine through thyroid function on metabolic disordersRecently, a study published in the authoritative journal Thyroid, the field of thyroid disease, looked at the relationship between iodine status and metabolic disorders such as metabolic syndrome, high blood pressure, impaired sugar metabolism, central type obesity and abnormal blood lipidsthe study included 51,795 subjects from the TIDE (National Epidemiological Crosssection Study of Thyroid Disease, Iodine Status and Diabetes) project, which was 18 years of ageThe researchers used a card method to calculate the prevalence of metabolic disorders and related diseases based on urine iodine concentration (UIC) levelsThe researchers used the logistic regression model of secondary and UIC stratification to further explore whether prevalence was associated with UICUIC has a u-type relationship with the prevalence of metabolic disorders, which is as low as 76.0% in the 300-499?g/L rangeThe participantSIc was 300-499?g/L and related to metabolic disorders (OR-0.857, 95% confidence interval (0.796-0.922) and hypertension (OR-0.873,95% confidence interval (0.814-0.936)UIC is 300-799 ?g/L associated with metabolic syndrome and impaired fasting blood sugar (IFG)The UIC is 500-799 ?g/L associated with prediabetes (OR-0.883, 95% confidence interval (0.797-0.978)UIC is associated with hypertriglyceride, hypercholesterolemia, and high levels of LDL-CIn addition, UIC is associated with hypertension (OR-1.097, 95% confidence interval (1.035-1.162) and hypercholesterolemia (OR-1.178,95% confidence interval (1.117-1.242)it is shown that adult UICs are u-typeassociated with metabolic disorders and their associated componentsThe association between UIC and metabolic disorders disappears in the case of iodine deficiency (?100?g/L) or excess (?500?g/L)