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Researchers from the University of Exeter School of Medicine in the UK and the University of Zaragoza in Spain have revealed the complexity of the trillions of microbiomes in the gut and the interactions between the gut microbiome and the body. In the
article, the researchers delved into a protein called TLR2, a key detector of the microbiome in the body's gut that regulates levels of serotonin, a neurotransmitter that carries information into the brain, which also exists in the gut and regulates intestinal behavior.
The researchers used cultured cells to study the results in mice, and found that gut microorganisms were able to interfere with the physiological properties of the body by regulating the activity of serotonin transport proteins, which are the target of treatment for a variety of diseases, and that the microbiome in the body's intestines was able to interfere with the transport protein and control serotonin levels.
The study sheds light on the complex link between the body's microbiome and human health, and even emotions, and researchers in California recently found that bacteria in the gut play a key role in causing Parkinson's disease.
this paper can also help explain the molecular mechanisms of the gut microbiome that affect the physiological properties of the body.
Inflamed bowel disease is induced when TLR2 functions abnormally, but so far, researchers do not fully understand the molecular mechanism behind the occurrence of inflammatory enteropathy, the researchers in this paper hope to further analyze the pathogenesis of inflammatory enteropathy.
researcher Eva Latorre says the TLR2 protein can change the availability of serotonin, which plays a key role in a variety of diseases, including depression and inflammatory bowel disease, so we need to do a number of studies to clarify the complex link between gut bacteriocytes and body health, and eventually develop new treatments for a variety of diseases.
researchers studied human cells in the intestinal model in the lab, delved into the molecular mechanisms of the body's expression of proteins and RNA, and how this expression activity affected the body's behavioral changes, and eventually found that the TLR2 protein was able to control serotonin transport proteins, as was the case in mice. Professor Jose E Mesonero, a
researcher, points out that this study expands our understanding and vision of the human body's microbiome, and ultimately we find that the TLR2 protein not only detects the microbiome, but also regulates the body's serotonin transport protein, a key mechanism for the occurrence of neurological and inflammatory diseases in the body, although more research is needed later to better understand the link between the human gut and brain, which is mediated by gut microorganisms.
: Intestinal Serotonin Transporter Regency by Toll-Like Receptor 2 Activation.A Feedback Modulation.Latorre E1, 2, Layunta E1, 3, Grasa L1, 3, Castro M1, 3, Pardo J4, Gomollón F5, Alcalde AI1, 3, Mesonero JE1, 3.