To ensure the stability of drugs, the maintenance of coating equipment should not be ignored

The so-called coating is to coat the sugar or other film-forming materials on the external surface of the solid pharmaceutical preparations in a specific equipment according to a specific process, so that they can become a layer or several layers of multi-functional protective layers with different thickness and elasticity tightly adhered to the surface after drying In the production of pharmaceutical preparations, coating is one of the important operation units The coating of tablets is to pack appropriate coating materials on the surface of tablets (core), so as to improve the appearance of tablets, cover some bad smell, and improve the stability and efficacy of drugs (to ensure the stability of the drug coating equipment maintenance gate can not be ignored picture source: Baidu picture) the author understands that according to the different coating materials, it can be divided into sugar coating, semi film coating, film coating, enteric coating and special material coating According to the different coating technology, it can be divided into spray coating, dip coating, dry pressing coating, electrostatic coating, laminating coating and so on However, regardless of different materials or different technologies, the core equipment of coating is the coating machine Common coating machines mainly include ordinary coating machine, fluidization coating machine, mesh coating machine, etc Specifically, the common coating machine is mainly composed of coating pot, power system, heating system and exhaust system Ordinary coating machine is a basic and commonly used roller coating equipment, which is widely used in domestic pharmaceutical enterprises When talking about the operation principle of the machine, some experts said that the ordinary coating machine is to blow hot air to the surface of the tablet when it is drying, and then it will be extracted by the exhaust system after being returned, and the heat will be exchanged in the surface layer In addition, some hot air may also be directly extracted by the exhaust system Therefore, the thermal energy utilization rate of ordinary coating machine is low, and the drying speed is slow Compared with the speed and heat utilization rate of ordinary coating machine, fluidizing coating machine not only has high speed and efficiency, but also uses less materials (film coating materials generally increase the weight of tablets by 2% ~ 4%), has strong moisture-proof ability, has little impact on the interpretation of avalanche, and is not limited by the shape of tablets, etc In addition, with the popularity of automation, the automation level of fluidization coating machine is also high But every equipment has its advantages and disadvantages, so does the fluidizing coating machine According to industry insiders, the coating layer of the fluidizing coating machine is thin, the coat is fragile, the color is not good, and it is not as beautiful as sugar coated tablets One of the major characteristics of mesh coating machine is that it can reduce the flying dust during production Now, mesh coating machine is undoubtedly an ideal equipment for environmental protection In addition to being environmentally friendly, the mesh coating machine has fast drying speed and short production cycle Specifically, it takes about 3 hours to pack a pot of tablets In addition, the heating time of the mesh coating machine to the drug core is also short, which can ensure the quality of drugs, save manpower and material resources, and reduce the production cost Like fluidization coating machine, mesh coating machine is highly automatic and easy to operate, which is widely used in the production of large pharmaceutical enterprises At present, there are various kinds of coating equipment, but with the development of technology and rapid progress, pharmaceutical companies also make difficulties in selecting equipment Some experts suggest that pharmaceutical enterprises should consider the product characteristics, the size of tablets, the fragility, hardness, and the characteristics of the drug itself according to the actual needs, so as to choose the equipment suitable for their own production In addition, experts also said that the key to coating operation is to master the relationship among temperature, spray rate and rotation speed Enterprises should also pay attention to the daily maintenance of the coating machine If you want to extend the service life of a device, you can't do without daily maintenance Taking the small-scale coating machine as an example, the equipment is mainly suitable for pharmaceutical, chemical, food and other industries It is suitable for tablet, pill packaging sugar coating, roll food and chemical products Some coating equipment manufacturers said that for the daily maintenance of the small coating machine, the following five points should be done: the lubricating oil in the gearbox and the lubricating grease in the inner cavity of the rolling bearing should be replaced regularly Second, if the coating pot is not used for a long time, it should be cleaned and coated with oil Third, the spray gun shall be washed with clear water under pressure after use in each shift to prevent mouth plugging In case of mouth blocking, the operator shall disassemble the nozzle according to the instructions of the spray gun, and clean the nozzle residue with a fine needle Fourth, in order to ensure that the worm gear in the gearbox meets the lubrication conditions of the transmission, the temperature rise of the gearbox in operation shall not exceed 50 ℃ Fifth, the oil proof sealing ring at the worm shaft end should also be inspected and replaced regularly With the rapid growth of the demand of pharmaceutical market, pharmaceutical enterprises have more and more demand for pharmaceutical machinery and equipment As an essential equipment in the pharmaceutical process, the coating equipment, in addition to constantly enriching in types, has shown leapfrog progress in technology In the face of various and advanced coating equipment, pharmaceutical companies need to start from the reality, choose the coating machine suitable for the shape and specification of drugs, and do a good job in future maintenance and repair.