To evaluate the effect of anti HCV therapy on the prognosis of HD patients
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Last Update: 2017-12-19
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Source: Internet
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Author: User
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Chronic hepatitis C (CHC) infection not only directly affects the liver, but also is related to extrahepatic manifestations, including kidney disease, the most common is membranoproliferative glomerulonephritis with or without cryoglobulinemia Some studies have shown that chronic hepatitis C (CHC) infection has a negative impact on renal function and survival in patients with chronic kidney disease (CKD) or hemodialysis (hd) Researchers from the University of Rawlins card University in Sweden conducted a nationwide registration study to describe the incidence rate of chronic kidney disease (CKD) or hemodialysis (HD) in CHC patients In addition, the researchers also evaluated the impact of anti HCV therapy on the prognosis of HD patients According to the international classification of diseases (ICD) - 10 standard, CHC patients and CKD patients were identified in Swedish inpatients (1997-2013) and non primary outpatient patients (2001-2013) For each HD patient, five non CHC controls were matched from the general population by age / gender / residence The follow-up period was from the diagnosis date of CHC to death, immigration or December 31, 2013 The results show that between 2001 and 2013, 42522 patients were diagnosed with CHC During a follow-up of 280123 persons a year, 2.5% (1077 / 45222) of the patients were diagnosed as CKD, while the data of the matched general population control group (1504765 persons a year) was 0.7% (1454 / 202694) Patients with CHC had a 3.3 to 7-fold increased risk of requiring hemodialysis (hd) Overall, 17% of CHC / HD patients received anti HCV treatment; 24% of the patients in the treatment cohort died, compared with 56% in the untreated cohort (P < 0.0001); anti HCV treatment improved the survival rate, and the odds ratio (or) was 3.901 (P = 0.001) The results of the national registry study showed an increased risk of CKD and dialysis in patients with CHC In addition, hepatitis C treatment appears to improve the survival of CHC / HD patients compared to untreated CHC / HD patients.
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