-
Categories
-
Pharmaceutical Intermediates
-
Active Pharmaceutical Ingredients
-
Food Additives
- Industrial Coatings
- Agrochemicals
- Dyes and Pigments
- Surfactant
- Flavors and Fragrances
- Chemical Reagents
- Catalyst and Auxiliary
- Natural Products
- Inorganic Chemistry
-
Organic Chemistry
-
Biochemical Engineering
- Analytical Chemistry
- Cosmetic Ingredient
-
Pharmaceutical Intermediates
Promotion
ECHEMI Mall
Wholesale
Weekly Price
Exhibition
News
-
Trade Service
▎Editor of WuXi AppTec's content team On June 7, the US FDA announced the approval of aducanumab, a monoclonal antibody therapy for Alzheimer's disease (AD), to accelerate the approval channel to market
.
As a new treatment for Alzheimer's disease approved by the FDA for the first time since 2003, this drug has undoubtedly attracted great attention
.
It is worth mentioning that the FDA also requested that this new treatment will need to be followed by confirmatory clinical trials to prove that it can indeed give patients significant cognitive benefits, such as improving memory, language, and orientation
.
Otherwise, the FDA has the right to withdraw the approval
.
Image source: 123RF With age, the decline in cognitive ability seems inevitable.
After suffering from Alzheimer's disease or other forms of dementia, the decline is particularly severe
.
In the past two decades, many scientific researchers have focused on the development of drugs for the treatment of Alzheimer, hoping to reverse the cognitive decline of patients, but many drug candidates failed to achieve the expected success in clinical trials
.
This has also led to many scientists in addition to drug treatments beginning to reach a consensus: to successfully fight Alzheimer's disease, delaying or preventing the occurrence of the disease will be the key
.
As for how to prevent, more and more evidence suggests that a healthy life>
.
In 2020, a report from the "Lancet" committee assessed that approximately 40% of cases of dementia can be delayed or prevented through life>
.
Among them, the factors that can be changed or interfered include diabetes, hypertension, tobacco, obesity, lack of exercise and so on
.
Image source: 123RF Recently, an article published in the "Science" magazine focused on about 30 studies currently carried out or planned to explore how to formulate reasonable interventions in diet, exercise and other life>
.
Life>
.
For example, in terms of diet, the so-called "Mediterranean diet", which is a diet plan rich in olive oil, fish and whole grains but less red meat and sugar, can improve certain aspects of cognition
.
Nevertheless, the researchers pointed out that the effects of life>
.
Professor Kristine Yaffe of the University of California, San Francisco (UCSF) believes: "A large number of observational studies have pointed out various factors that affect cognitive aging, but I don't think that this factor or that factor is sufficient to prevent Alzheimer's disease
.
" Image source : 123RF In order to confirm the value of various interventions, scientists hope to provide supporting evidence through strictly set randomized controlled clinical trials and find effective intervention programs
.
For example, a three-year study that will end later this year was conducted among 600 people at high risk of dementia over the age of 60, and evaluated the Mediterranean diet and the DASH diet (a diet plan to control high blood pressure).
Whether it can delay the occurrence of neurodegenerative diseases
.
"Whether diet changes can prevent cognitive decline in the elderly, this study may provide the first evidence
.
"The leader of this trial, Professor Lisa Barnes, a cognitive neuropsychologist at Rush University in the United States, said
.
However, random trials like this that only focus on a certain aspect of life>
.
Many researchers believe that dementia such as Alzheimer's disease is caused by a variety of reasons, and prevention requires multiple interventions and multi-pronged measures
.
Image source: 123RF For this reason, some aim to examine the comprehensive impact of multiple interventions The clinical trial of the company will provide a better opportunity to find meaningful intervention effects
.
A clinical trial launched in Finland in 2009 is the famous FINGER study (the "Finnish Geriatric Intervention Study for the Prevention of Cognitive Impairment and Disability" ) Is one of the pioneers
.
This study included 1,260 elderly people
in
their 60s and 70s .
These elderly people are susceptible to dementia due to risk factors such as high blood pressure .
Half of them have participated in an "intensification program" that comprehensively improves their diet and exercise.
habits, cardiovascular health and to participate in social and cognitive training, control group that received health counseling but did not get help on the monitoring and implementation
.
after two years, participants plan to strengthen the improved scores in cognitive tests in
.
"this It is the first study to prove that comprehensive interventions can affect cognition on this scale and scope
.
"Alzheimer's disease research expert Dr.
Heather Snyder commented
.
The continued follow-up of these participants may also tell us how long the cognitive benefits of improving life>
.
Image source: 123RF At present, research institutions in many countries and regions around the world are promoting similar comprehensive intervention research methods to investigate whether interventions tailored to the diet and living habits of their respective populations can reproduce the results of the FINGER trial
.
For example, in Australia, in an experiment called "Maintain Your Brain" (Maintain Your Brain), about 6000 middle-aged and elderly people have worked hard to boost iron, eat vegetables and whole grains in the past 3 years to relieve stress.
Play intellectual games on the computer in order to examine whether this package can protect cognition and even prevent dementia
.
So far, whether life>
.
Dr.
Laura Baker, an expert in charge of a clinical trial of this kind in the United States, believes: "In the next ten years, we will see whether life>
.
"Reference material[1] Can diet and exercise lower your risk of dementia? Rigorous clinical trials aim to find out.
Retrieved June 8, 2021 from https:// and-exercise-lower-your-risk-dementia-rigorous-clinical-trials-aim-find-out[2] Liu X et al.
, (2021) Mediterranean-DASH Intervention for Neurodegenerative Delay (MIND) study: Rationale, design and baseline characteristics of a randomized control trial of the MIND diet on cognitive decline.
Contemp Clin Trials.
doi: 10.
1016/j.
cct.
2021.
106270.
[3] Maintain Your Brain: Protocol of a 3-Year Randomized Controlled Trial of a Personalized Multi -Modal Digital Health Intervention to Prevent Cognitive Decline among Community Dwelling 55 to 77 Year Olds.
Retrieved June 8, 2021 from https://research-repository.
uwa.
edu.
au/en/publications/maintain-your-brain-protocol-of-a-3-year-randomized-controlled-tr
.
As a new treatment for Alzheimer's disease approved by the FDA for the first time since 2003, this drug has undoubtedly attracted great attention
.
It is worth mentioning that the FDA also requested that this new treatment will need to be followed by confirmatory clinical trials to prove that it can indeed give patients significant cognitive benefits, such as improving memory, language, and orientation
.
Otherwise, the FDA has the right to withdraw the approval
.
Image source: 123RF With age, the decline in cognitive ability seems inevitable.
After suffering from Alzheimer's disease or other forms of dementia, the decline is particularly severe
.
In the past two decades, many scientific researchers have focused on the development of drugs for the treatment of Alzheimer, hoping to reverse the cognitive decline of patients, but many drug candidates failed to achieve the expected success in clinical trials
.
This has also led to many scientists in addition to drug treatments beginning to reach a consensus: to successfully fight Alzheimer's disease, delaying or preventing the occurrence of the disease will be the key
.
As for how to prevent, more and more evidence suggests that a healthy life>
.
In 2020, a report from the "Lancet" committee assessed that approximately 40% of cases of dementia can be delayed or prevented through life>
.
Among them, the factors that can be changed or interfered include diabetes, hypertension, tobacco, obesity, lack of exercise and so on
.
Image source: 123RF Recently, an article published in the "Science" magazine focused on about 30 studies currently carried out or planned to explore how to formulate reasonable interventions in diet, exercise and other life>
.
Life>
.
For example, in terms of diet, the so-called "Mediterranean diet", which is a diet plan rich in olive oil, fish and whole grains but less red meat and sugar, can improve certain aspects of cognition
.
Nevertheless, the researchers pointed out that the effects of life>
.
Professor Kristine Yaffe of the University of California, San Francisco (UCSF) believes: "A large number of observational studies have pointed out various factors that affect cognitive aging, but I don't think that this factor or that factor is sufficient to prevent Alzheimer's disease
.
" Image source : 123RF In order to confirm the value of various interventions, scientists hope to provide supporting evidence through strictly set randomized controlled clinical trials and find effective intervention programs
.
For example, a three-year study that will end later this year was conducted among 600 people at high risk of dementia over the age of 60, and evaluated the Mediterranean diet and the DASH diet (a diet plan to control high blood pressure).
Whether it can delay the occurrence of neurodegenerative diseases
.
"Whether diet changes can prevent cognitive decline in the elderly, this study may provide the first evidence
.
"The leader of this trial, Professor Lisa Barnes, a cognitive neuropsychologist at Rush University in the United States, said
.
However, random trials like this that only focus on a certain aspect of life>
.
Many researchers believe that dementia such as Alzheimer's disease is caused by a variety of reasons, and prevention requires multiple interventions and multi-pronged measures
.
Image source: 123RF For this reason, some aim to examine the comprehensive impact of multiple interventions The clinical trial of the company will provide a better opportunity to find meaningful intervention effects
.
A clinical trial launched in Finland in 2009 is the famous FINGER study (the "Finnish Geriatric Intervention Study for the Prevention of Cognitive Impairment and Disability" ) Is one of the pioneers
.
This study included 1,260 elderly people
in
their 60s and 70s .
These elderly people are susceptible to dementia due to risk factors such as high blood pressure .
Half of them have participated in an "intensification program" that comprehensively improves their diet and exercise.
habits, cardiovascular health and to participate in social and cognitive training, control group that received health counseling but did not get help on the monitoring and implementation
.
after two years, participants plan to strengthen the improved scores in cognitive tests in
.
"this It is the first study to prove that comprehensive interventions can affect cognition on this scale and scope
.
"Alzheimer's disease research expert Dr.
Heather Snyder commented
.
The continued follow-up of these participants may also tell us how long the cognitive benefits of improving life>
.
Image source: 123RF At present, research institutions in many countries and regions around the world are promoting similar comprehensive intervention research methods to investigate whether interventions tailored to the diet and living habits of their respective populations can reproduce the results of the FINGER trial
.
For example, in Australia, in an experiment called "Maintain Your Brain" (Maintain Your Brain), about 6000 middle-aged and elderly people have worked hard to boost iron, eat vegetables and whole grains in the past 3 years to relieve stress.
Play intellectual games on the computer in order to examine whether this package can protect cognition and even prevent dementia
.
So far, whether life>
.
Dr.
Laura Baker, an expert in charge of a clinical trial of this kind in the United States, believes: "In the next ten years, we will see whether life>
.
"Reference material[1] Can diet and exercise lower your risk of dementia? Rigorous clinical trials aim to find out.
Retrieved June 8, 2021 from https:// and-exercise-lower-your-risk-dementia-rigorous-clinical-trials-aim-find-out[2] Liu X et al.
, (2021) Mediterranean-DASH Intervention for Neurodegenerative Delay (MIND) study: Rationale, design and baseline characteristics of a randomized control trial of the MIND diet on cognitive decline.
Contemp Clin Trials.
doi: 10.
1016/j.
cct.
2021.
106270.
[3] Maintain Your Brain: Protocol of a 3-Year Randomized Controlled Trial of a Personalized Multi -Modal Digital Health Intervention to Prevent Cognitive Decline among Community Dwelling 55 to 77 Year Olds.
Retrieved June 8, 2021 from https://research-repository.
uwa.
edu.
au/en/publications/maintain-your-brain-protocol-of-a-3-year-randomized-controlled-tr
