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Toad venom base
Cinobufagin
[Synonyms] Huabufaxin, Huabufazi, Huabufajing
【Structural formula】
[Molecular formula and molecular weight] C 26 H 34 O 6 ; 442.
[Source] Bufobufo gararizans Gantor or Bufobufo gararizans Gantor or Bufobufo gararizans Gantor or Bufomela-nostictus Schneider
【Properties】White square crystal
This product is soluble in chloroform
Melting point: 213~215℃
【Purity Check】
TLC
1.
Developing solvent cyclohexane - chloroform - acetone (5:3:3)
Check under UV light (254nm) before color development, and under sunlight after color development with 10% sulfuric acid ethanol
2.
Developing solvent cyclohexane - chloroform - ethanol - acetic acid (10: 10: 1 1)
Check under the ultraviolet light (254nm) before the color development, and check the high performance liquid chromatography under the sunlight after the color development with 10% sulfuric acid ethanol
Column DiamansilTM C 18 , 5um (4.
Mobile phase acetonitrile-water (53:47), 1.
Detection wavelength 295nm
Differential calorimetry
Start temperature 40℃, end temperature 250℃, heating rate 5℃/min
【Structural identification】295,202
3454, 2914, 1736, 1712, 1549, 1450, 1385, 1234, 1215, 1136, 1038, 958, 881, 845
ESI-MS m/z: 443[M+H] + , 425, 382, 364, 250, 233, 215, 203
1 H-NMR (CDCl 3 ) δ: 7.
13 C-NMR (CDCl 3 ) δ: 29.
【Storage】Dry and airtight
Related Links: Evodia