TOFT theory new sound.

Professor Soto, an advocate of tissue field theory (TOFT), recently re-voiced an article in Plos Biology entitled Over a century of cancer research: Inconvenient truths and leads denouncing mainstream somatic cell mutation (SMT) oncology theory that cancer treatment has been slow over the past century because the conceptual framework is wrong.
TOFT theory holds that changes such as cell nuclei, cell membranes, mitochondrials, ER, metabolism and other changes in cells have little to do with tumors, and that genetic variation has nothing to do with tumor occurrence, but is only an accompanying phenomenon.
The theory holds that the loss of tissue level is the cause of tumors, that cells are born to divide and metasnot, that do not require cancer-causing gene mutations to grow, and that tissue restrictions called morphological formation are the ones that form the order that sustain normal life.
the authors argue that tumor formation is reversible, as clinically sometimes sees in self-healing.
of drug sources There are two main theories for tumor occurrence, namely SMT theory and THIST theory.
the former believes that cell mutations are the root cause of tumors, while the latter believes that out-of-control tissue levels are the root cause.
SMT is an absolute mainstream theory, one is that it is easier to understand and the other is easier to operate.
, such as a riot somewhere, it's easy to understand that these people drink too much together.
it's easy to distinguish between these people and normal people, just measure the alcohol content.
treatment is also relatively simple, blocking alcohol intake can be.
that the tumor originated from a genetic mutation and was supported by a cancer-causing trial that induced the mutation.
But TOFT countered that no one had ever done an experiment to put a single cell with enough mutated genes into normal tissue to produce an observable tumor, predicting that the cell would not survive no matter how many cancer-causing gene variants in a normal tissue environment.
group of perfectly normal, alcohol-free people can also do more terrible things than drunks, such as some of the most unseginable years in history.
normal cells that don't mutate just because of changes in tissue structure can also become tumors? One of toFT's most critical experiments was to isolate the cytosyl and endotour cells in rats and then pair the two cell substates with two cellular substates and two pairs of endotyl cells, respectively, resulting in tumors in only the two groups of cytokinal cancer, and cancerous endotyl cells in the normal cytokine and unable to produce tumors.
TOFT supporters say the experiment shows that changes in tissue structure cause tumors rather than mutated cells.
unfortunately, such experiments are rare and have not been repeated or cross-validated in other species.
reported in mice that cancerous cortectal cells were found to produce tumors, so the SMT theory is supported.
tumor is a tissue disease no doubt, cell level effective anti-tumor cell drugs to the whole animal or patient ineffective is a common phenomenon.
And many of the drugs that are clinically effective actually have little to do with killing tumor cells at the cellular level, such as yew alcohol, which does not effectively kill tumor cells at therapeutic concentrations, but causes the collapse of the entire tissue after the tissue level can kill some specific cells.
also have drugs that can kill tumor cells but promote tumor growth at the tissue level, because tumors are a complex division of labor, mutually restricted tissue, some people passively idle, some people drag their feet.
this part of the tumor may instead increase the viability of the entire tumor, drug resistance can also be understood as the loss of part of the tumor cells after the entire tumor tissue survival capacity.
smT now recognizes the importance of tumor micro-environments, and the emerging immunotherapy does not directly kill tumor cells, but disarms tumor tissue against the immune system.
the fundamental problem of TOFT is that there is no reliable experimental system to define tissue loss of control, so it is difficult to guide drug development as a conceptual framework.
Almost all cancer drugs affect cell genes, metastatics, various signaling molecules, etc., and such complex cellular level changes in tissue levels are evaluated beyond current technical capabilities.
the tissue structure of patients simulated with experimental animals is also blank.
so SMT became mainstream on the one hand, there is a lot of data support, there is a certain credibility, but also because it is more technically feasible.
, as Aesop's fable says, a place with good light is easier to find, but not necessarily a place where you lose your keys.
theory is always tearing down the east wall to make up the west wall, carcinogenic genes more and more.
, who has been wanted for years, has not improved his security, and it is even more doubtful how important the other little ones really are.
the use of CRISPR technology last year to remove common cancer drug targets, many drugs can still kill tumor cells, indicating that the efficacy of many drugs is not related to target activity.
say SMT, if it's wrong, how do you explain so many successful drugs? In fact, 95% of the preclinical effect of good drugs to the clinical failure, the remaining successful drugs have been very harsh purification screening, there are serious survivor bias.
as the joke goes, you do push-ups in the elevator to the top floor not because you're push-ups, but because the elevator is working.
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