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    Home > Active Ingredient News > Drugs Articles > Traceability management system helps to realize the safety production of aloe pieces

    Traceability management system helps to realize the safety production of aloe pieces

    • Last Update: 2017-08-18
    • Source: Internet
    • Author: User
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    [China Pharmaceutical network industry trends] the media communication meeting on standardized production technology and industrialization of raw materials of Chinese herbal pieces of Chenxiang was held in Guangzhou on August 17 Professor Shi Xuguang, professor and doctoral supervisor of the teaching and Research Office of prescriptions, Guangzhou University of traditional Chinese medicine, and Guangdong Chenxiang planting research expert/ Mr LAN Junzhi, director of Zhongshan Senbao Chenxiang comprehensive technology research institute and Mr Liang Yong, chairman of Guangdong Desheng Chenxiang Industry Development Co., Ltd., attended the media communication meeting and answered the media questions on relevant technical issues (traceability management system helps to realize the safe production of aloe decoction pieces pictures source: Baidu pictures) the eccentric perfusion method and other artificial aroma forming technologies can improve the quality and output of aloe Recently, the "standardized production technology and industrialization of raw materials of aloe decoction pieces" developed by Guangdong Baosheng aloe planting Co., Ltd Scientific and technological achievements, under the auspices of China Hi Tech Industrialization Research Association, passed the expert evaluation meeting and were highly recognized by the participating experts Du Guanhua, deputy director of the Institute of medicine of the Chinese Academy of Medical Sciences, ye Zuguang, researcher of the Institute of traditional Chinese medicine of the Chinese Academy of Medical Sciences, Zhang Heqiu, deputy director of the Research Office of the Institute of basic medicine of the Academy of Military Medical Sciences, and director of the experimental research center of Xiyuan Hospital of the Chinese Academy of Medical Sciences/ Liu Jianxun, vice president, and other experts and scholars attended the evaluation meeting The participating experts believed that the research results of the undergraduate course had reached the international level in the standardized production technology of raw materials of Chinese herbal pieces of aloe, which was helpful to solve the problem of shortage of raw materials of Chinese Herbal Pieces of aloe, and had a broad market application prospect According to the participating experts, the main innovation points of the scientific and technological achievements are "the eccentric pouring method for the production of aloes" and "a production method of plate aloes" This technology has achieved the technical problems of fixing and fixing the aroma in the production of aloe tuber, which makes the aloe tuber present honey flavor, and the storage time and quality are close to the wild high-quality aloe tuber The raw materials of Jiexiang have passed the test of SGS, and all of them do not contain substances harmful to human body After the multi batch test of China food and Drug Control Research Institute, Guangdong Provincial Drug Inspection Institute, Shenzhen Drug Inspection Research Institute, China Guangzhou analysis and test center and other professional organizations, all the products of this technology conform to the Chinese Pharmacopoeia 2015 Version of aloe standard, so that the ancient precious Chinese herbal medicine has a technical basis for industrialization   Mr LAN Junzhi, the inventor of the technology, said that the eccentric pouring method is to drill at least one hole which is laterally eccentric and inclined on the trunk of aloes, and then inject the gland activator into the tree slowly through the hole pouring method, and seal the hole after the pouring is completed After the aloes grows for a period of time, it will be cut and formed in the xylem of the trunk The outer two layers of brown oil and yellow brown discolored xylem are dried to be aloe "The eccentric perfusion method drills one or two eccentric and downward holes from the base of the trunk 30-40cm away from the ground, so as to form a high node perfusion system on the trunk of Agaricus, and evenly transport the gland activator to all parts of the tree, so as to form the tuber, greatly improving the quality and yield of Agaricus "Mr LAN junchi told reporters that the eccentric perfusion method can not only ensure that the fragrance gland activator is not easy to flow out during perfusion, but also can play the role of tree heart activation In addition to the increase of fragrance yield by more than 30%, it also effectively shortens the production cycle of aloe, which has important ecological, economic and cultural benefits The traceability management system realizes the scientific management and safe production of aloe decoction pieces "Aloe is a kind of resin containing wood formed in the process of self repair after being injured by nature, which is the product of stress response of the tree But for a long time, the wild resources of the tree are scarce and the ecological environment is damaged 1987 Baimuxiang was listed as the "national endangered third class protected plant" in 1999, and approved as the "national second class key protected wild plant" by the State Council in 1999 In the same year, it was listed in the "China plant red book" as a comprehensive controlled protected species In 2005, it was listed in the "Convention on international trade in endangered species of wild animal and plant species" In 2017, it was listed in the "Regulations on the protection of Chinese herbal medicines in Lingnan, Guangdong Province" "Liang Yong, chairman of Guangdong Desheng Chenxiang Industrial Development Co., Ltd., said "It will take decades or even hundreds of years to generate wild natural aloe, and it is difficult to generate, with low output However, due to its wide use and strong market demand, the price keeps rising Since modern times, artificial aroma forming technology has become an important means for people to obtain aloe, but due to the uneven technical level, the standard of aloe can not meet the requirements of Chinese Pharmacopoeia 2015 "Mr LAN junchi introduced that the scientific and technological achievement of standardized production technology and industrialization of raw materials of traditional Chinese medicine of aloe, whose innovation lies in the realization of the stability of quality and the predictability of output of aloe, and the application of dual QR code and RFID in the whole process Chip and traceability management system, a scientific, controllable and traceable production system based on the monitoring technology of Sinology, has realized the standardized production of traceable Chinese herbal pieces "When the trunk is 8-10cm in diameter, using the huge transpiration tension produced by the transpiration of the white wood incense tree itself, the fragrance gland activator is injected into the main pole of the tree by the method of eccentric perfusion, and the amount of the fragrance gland activator is determined according to the different volume and height of each tree "Liang Yong, chairman of Guangdong Desheng Chenxiang Industry Development Co., Ltd., introduced that through years of large-scale production experiments on nearly 200000 white wood incense in Yunnan, Hainan, Guangxi, Guangdong and other planting bases, it was found that the Chenxiang produced by this technology has the characteristics of cross region, large area, high quality, stable and stable production, and the production cycle of Chenxiang does not exceed five years "According to the first part of the Chinese Pharmacopoeia, 2015 edition, the ethanol extract of aloe pieces shall not be less than 10.0% and the content of aloe tetranol shall not be less than 0.1% According to our own sampling test, the ethanol extract of aloe pieces shall be between 15.58% and 20.11%, and the content of aloe tetranol shall be between 0.51% and 1.55%, which is completely higher than the requirements of the Chinese Pharmacopoeia "Liang Yong said that the quality standards of Baosheng Chenxiang also exceeded the requirements of 2015 edition of Chinese Pharmacopoeia, according to the inspection of relevant institutions such as CFDA, Guangdong Institute of drug control, Shenzhen Institute of drug control, etc In compendium of Materia Medica, Li Shizhen recorded that Chenxiang "can cure the heat and cold, reverse the breath, empty the large intestine, urinate and drench, and cool the essence of men" According to Chinese Pharmacopoeia, the taste of aloe is pungent, bitter and mild, and the meridians are spleen, stomach and kidney "Through the study of the literature of Chenxiang, it is found that Chenxiang has a wide range of medicinal value, especially in the treatment of stomach distention, abdominal distention, stomach pain, abdominal pain and other digestive system discomfort, in the treatment of angina pectoris, myocardial infarction, chest distress; kidney deficiency, poor urination, abdominal pain and sedative sleep "Professor Shi Xuguang, doctoral supervisor of the teaching and Research Office of prescriptions of Guangzhou University of traditional Chinese medicine, said "Chenxiang is a precious traditional Chinese medicine which has a long history in China It is a treasure in the history of traditional Chinese medicine It was recorded in the collection of Materia Medica in the Tang Dynasty, the materia medica in the Five Dynasties, the compendium of Materia Medica by Li Shizhen in the Ming Dynasty and the medical records of famous doctors in the late Han Dynasty "Professor Shi Xuguang said that in the past 1500 years, there are 795 prescriptions with aloe ingredients recorded in the ancient books of traditional Chinese medicine, including 1168 prescriptions In the 2015 edition of the Chinese Pharmacopoeia, there are 38 Chinese patent medicines with aloe ingredients, 936 manufacturers, involving 954 approval numbers "2 - (2-phenylethyl) chromones are one of the main active components of aloe, which have different degrees of antiallergic and neuroprotective activities The essential oil of aloe has the activity of bacteriostasis and sedation, and this kind of component has good specificity, which is an important landmark component in the quality evaluation of aloe "Professor Shi Xuguang believes that with the progress of modern science, the research on the chemical constituents of aloe is gradually deepened by professionals, and the correlation between the unique constituents and the quality of aloe begins to be concerned "Gufang's corresponding users are the hospital and drugstore 100 sub cabinet market, with an estimated annual market scale of 200 tons; the pharmaceutical factory's annual market feeding scale of 200 tons; the boutique retail market's annual sales volume of about 200 tons, with a total scale of about 600 tons It is estimated that 6 million trees will need to be planted to meet the market demand based on the calculation of 100 grams of fragrance per 5-year-old tree "Liang Yong said that Guangdong Baosheng Chenxiang planting Co., Ltd has invested more than 100 million yuan for more than three years Its exploration and practice in the fields of Chenxiang production, product application research, industrial development mode, etc now has a stable, large-scale and high-quality industrialization foundation of Chenxiang traditional Chinese medicine drink tablets Even so, according to the data of minenet, the sales volume of many Chinese patent medicines containing aloe is not ideal in China, some of which only have a sales volume of more than 100000 yuan a year, and some of which can not be monitored at all "In November 2015, Fujian food and Drug Administration announced to the media the results of the sampling inspection of Chinese herbal medicines and pieces in 2015 Of the 672 batches and 145 varieties of Chinese herbal medicines and pieces, 124 batches were unqualified, with the unqualified rate of 18.5% Among them, the unqualified rate of aloe is as high as 100% "In this regard, Liang Yong, chairman of Guangdong Desheng Chenxiang Industry Development Co., Ltd., believes that due to the high price and unstable quality of Chenxiang on the market, the Chinese Pharmacopoeia now stipulates that Chinese medicine enterprises should feed pieces of Decoction in the production process, that is to say, the pure medicinal materials in the past However, because many pieces of aloe are not up to the standard, leading to the lack of this medicine and drug factories stop production, and the results of sampling inspection by Fujian Provincial Drug Administration also fully show that the quality problems of Chinese pieces of aloe have seriously hindered the healthy development of this industry   Liang Yong said that the cultivation, planting, harvesting, production and processing of aloes sounds simple In fact, it needs close division of work and cooperation between the upstream and downstream of the industrial chain to do a good job In order to let the results of artificial aroma forming technology such as eccentric perfusion method end up in pieces, Guangdong Desheng aloes Industry Development Co., Ltd has acquired Guangzhou Zhenlong Pharmaceutical Co., Ltd., mainly for the next generation It is a series of Chinese herbal pieces with the brand of "Xiang Shen Yao Shang" "The selection of domestic superior aloe, combined with the processing theory of traditional Chinese medicine, the use of modern Chinese medicine Pieces production technology, in strict accordance with the requirements of drug production GMP, from the purchase of raw materials - production process - the finished product factory has gone through 20 links, nearly 20 For inspection and inspection of items, each link is subject to quality risk assessment Each batch of raw medicinal materials of aloe has a specific code, and each batch of finished pieces of decoction has a complete file "Liang Yong said that only by formulating strict risk prevention and control measures can we produce quality and qualified Chenxiang products "On July 1, 2017, the Chinese medicine law of the people's Republic of China was officially implemented Article 24 of the law clearly stipulates that the State encourages the development of modern circulation system of Chinese medicine and improves technical water for packaging and storage of Chinese medicine
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