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    Home > Medical News > Medical Research Articles > TRANSCUTOL [Solvent] Diethylene glycol monoethyl ether

    TRANSCUTOL [Solvent] Diethylene glycol monoethyl ether

    • Last Update: 2021-07-29
    • Source: Internet
    • Author: User
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    transcutol [solvent]

    Chemical name : Diethylene glycol monoethyl ether

    English name : Diethylene glycol monoethyl ether

    Application :

    Solvents for many active drugs (such as: nitroglycerin, indomethacin, nifedipine, hormones, sterols);

    Absorption enhancer;

    It can be used for local administration, transdermal administration and preparation of oral preparations;

    Can be combined with LABRAFIL ? series of auxiliary materials and vegetable oil


    Appearance : colorless transparent liquid

    Solubility at 20°C (European Pharmacopoeia third edition):

    96% alcohol soluble

    Soluble in water

    Partially soluble in vegetable oil

    Insoluble in mineral oil

    Volatile compounds and organic solvents:

    In TRANSCUTOL ? Related to residual solvent is less than the limits specified in ICH


    Related organic solvents and limits in ICH:

    -2-Methoxyethanol: <50ppm

    -2-Ethoxyethanol: <160ppm

    -Ethylene glycol: <620ppm

    Toxicology :

    -Acute oral toxicity (rat): LD 50 >5000mg/kg


    -Reversible eye irritation (100%): No irritation


    -Eye irritation (30%): No irritation


    -Basic skin irritation (rabbit-50%/water): no irritation


    -Basic skin irritation (human -100%): no irritation


    -Skin sensitivity (100%): No sensitivity


    -28-day repetitive skin toxicity (rabbit): up to a non-toxic dose of 1000mg/kg/day


    Regulatory status : (1) USP-NF/EP/IIG

    (2) Documents are being prepared and IDL will be applied soon

    Packing : 25kg/drum, 200kg/drum

    Storage : Store in a cool and dry place, avoid exposure to air

     

    Supplier: Jiafa Shi

    Contact: Manager Liu

    Contact number: 139 1173 0390

    E-mail: eileenliu@gattefossecn.


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