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Cognitive dysfunction exists in various mental diseases.
4 4 Adult patients with chronic idiopathic constipation (CIC)
This trial aims to study the effects of procarlopride (6-day test) on behavior and neurological learning and memory processes over a longer period of time, including a memory paradigm known to be a reliable probe of hippocampal function and related circuits
This trial aims to study the effects of procarlopride (6-day test) on behavior and neurological learning and memory processes over a longer period of time, including a memory paradigm known to be a reliable probe of hippocampal function and related circuits
There was no significant difference in state anxiety or impact between the placebo group and the placebo group, and there was no significant difference in the side effects reported during the baseline or during the study visit.
In the post-scan recall task, the procapride group was more accurate than the placebo group in distinguishing the target image (novelty + familiarity) from the distractor (F(1,38) = 5.
Functional Magnetic Resonance Imaging for Memory Tasks: Treatment Effect-Analysis of Regions of Interest
Functional Magnetic Resonance Imaging for Memory Tasks: Treatment Effect-Analysis of Regions of Interest
Therapeutic effect-whole brain analysis: Compared with the placebo group, in the response to the familiar image in the right corner gyrus, the activity of the procapride group increased [Procapride > placebo, Z = 4.
Therapeutic effect——whole brain analysis: Compared with the placebo group, in the response to the familiar images in the right corner gyrus, the activity of the procapride group increased [Procapride > > placebo, Z = 4.
This research brings hope to the future use of 5-HT4 receptor agonists to improve some cognitive impairments related to mental disorders
Angharad N.
Translational Psychiatry (2021) 11:497; https://doi.
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