Transl Res: Wang Hui and Liu Ningning's team found that targeted anti-cancer drugs can enhance antifungal effects

Recently, Professor Wang Hui and Liu Ningning, a team of researchers from the School of Public Health of Shanghai Jiao Tong University School of Medicine, together with Professor Chen Changbin of the Shanghai Pasteur Institute of the Chinese Academy of Sciences, published a dual action small molecule enhances azoles and overcomes resistance through co-targeting in the internationally renowned journal Translational Research Research paper

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When Candida albicans infects a host, the host's epidermal growth factor receptor (EGFR) can mediate endocytosis of epithelial cells on Candida albicans, a key process

The study found that OSI combined with FLC has a broad-spectrum antifungal effect on a variety of fungal resistant strains, which on the one hand can inhibit the function of the drug excretion pump Pdr5, thereby inhibiting the external discharge of FLC, increasing the effective accumulation of FLC in cells, and enhancing its antifungal efficacy

The first author and the last corresponding author of this article are affiliated with Shanghai Jiao Tong University School of Medicine

Original source:

Liu NN, Zhou J, Jiang T, Tarsio M, Yu F, Zheng X, Qi W, Liu L, Tan JC, Wei L, Ding J, Li J, Zeng L, Ren B, Huang X, Peng Y, Cao YB, Zhao Y, Zhang XY, Kane PM, Chen C, Wang H.