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As we all know, the intestinal microbiome (microflora) known as the "second brain" of humans is related to various human diseases such as cancer, cardiovascular disease, type 2 diabetes, obesity and hypertension, as well as Alzheimer's and mental diseases.
Diseases are closely related
.
Because the intestinal flora directly affects the balance between the pro-inflammatory response that triggers the disease and the anti-inflammatory response that fights the disease in the intestine
.
A healthy intestinal ecosystem must be in a balanced and mutually beneficial state; otherwise, it will exhibit various health problems
.
Nowadays, fecal bacteria transplantation (FMT), which is very mature, treats diseases by rebuilding the patient's intestinal flora, that is, pouring treated healthy human fecal fluid into the patient's intestine
.
In 1958, American doctors used fecal fluid to save infected critically ill patients.
This is the earliest case recorded in English literature
.
In China, similar "fecal bacteria transplantation" has a history of at least 2000 years
.
In recent years, the incidence of Clostridium difficile infection (CDI) has been increasing around the world, which is also an important reason why stool transplantation is widely used in clinical practice
.
Clostridium difficile is a gram-positive anaerobic bacillus widely distributed in human and animal intestines and the environment.
It is one of the most common hospital-acquired infections
.
Clostridium difficile is transmitted through the fecal-oral route, and the most important risk factors include antibiotic treatment, the elderly, and hospitalization
.
The clinical manifestations range from asymptomatic carriers, to varying degrees of diarrhea, to the most serious, life-threatening colitis, which eventually leads to death
.
In an article published on "Gut" on July 7, Beijing time, a research team led by Warsaw Medical University in Poland reported that two cases of recurrence of Clostridium difficile infection were "a blessing in disguise" after receiving fecal bacteria transplantation and were quickly cured Of his own new coronary pneumonia
.
The situation is like this: Recently, an 80-year-old male patient with various comorbidities such as pneumonia and a 19-year-old male patient with ulcerative colitis caused by immunosuppression in Poland received recurrence of severe Clostridium difficile infection.
Fecal bacteria transplantation
.
The results of the nasopharyngeal swab and stool test of the two patients before the operation were negative
.
However, to the surprise of the doctors, both patients tested positive for the new crown 7 days after the fecal bacteria transplantation
.
Although they are all at high risk of severe new coronary pneumonia, their symptoms are only mild, and they recovered quickly after only a few days of fever
.
Although the 19-year-old patient had a compromised immune system and did not even receive treatment for the new coronavirus infection, he only developed a fever of 39 degrees 15 hours after the fecal bacteria transplantation.
Subsequently, his body temperature did not exceed 36.
6 degrees.
C-reactive protein (CRP) ) And interleukin-6 (IL-6) levels returned to normal
.
In other words, the originally weak patient recovered on his own in a short period of time
.
The 80-year-old patient had his fever gone two days after receiving the fecal bacteria transplant, and he did not experience any worsening of pneumonia
.
One possible explanation is that fecal bacteria transplantation can alleviate more adverse consequences by affecting the interaction between the intestinal flora and the immune system
.
This has given researchers new ideas, and they will soon carry out relevant clinical trials to determine whether stool transplantation can really help patients recover from new coronary pneumonia
.
Researchers said that if fecal bacteria transplantation is not carried out, they really don't know how these two frail patients will fight the new coronary pneumonia.
Of course, it is difficult for them to determine the reason for the rapid recovery of these two cases
.
But this coincidence is enough to cause scientists to conduct in-depth investigations
.
As we all know, the intestinal flora of an individual is closely related to its immune system
.
Infection with the new coronavirus can cause obvious gastrointestinal disorders
.
Previously, researchers have proposed to use fecal transplantation to restore the patient's damaged intestinal flora, and may affect their immune response, including the respiratory system (gut-lung axis)
.
There are also some preliminary studies that show that fecal bacteria transplantation can restore the balance of intestinal flora to a certain extent after infection with the new coronavirus
.
However, no one has so far conducted in-depth research on whether this therapy is clinically effective or even safe
.
Fecal bacteria transplantation will be carefully screened when used as treatment to prevent patients from being infected, but there will always be some dangerous pathogens sneaking into it
.
In the current global pandemic, this possibility is even greater
.
Nevertheless, the researchers believe that the rapid recovery of these two cases in Poland is worthy of further exploration
.
Most patients infected with the new coronavirus will detect the virus in the stool within about 28 days, but in these two cases, the viral material disappeared from the stool sample much faster
.
The researchers said that the main conclusion drawn from these two cases is that fecal microbiota transplantation appears to be safe and effective in treating recurrent Clostridium difficile infections in patients with new coronary pneumonia
.
Fecal bacteria transplantation may shorten the clinical course of new coronary pneumonia
.
For example, fecal bacteria transplantation may strengthen the immune system of patients with new coronary pneumonia, triggering a series of molecular changes after certain bacteria colonization
.
Some previous studies have shown that the intestinal flora can affect the respiratory system (gut-lung axis), and in turn, it can also increase the lungs' resistance to new coronary pneumonia
.
The mechanism is unknown, the intestinal flora
.
To date, scientists still have little knowledge of how the intestinal flora affects the immune system, and how fecal bacteria transplantation ultimately facilitates this process
.
But the researchers said that this treatment may really help patients clear serious viral infections
.
Therefore, based on the experience of these two cases and other data that proves that the human gut microbes and the immune system are mutually renting, the team is conducting a clinical trial to evaluate the impact of fecal bacteria transplantation in the standard treatment of new coronary pneumonia on reducing the course of the disease
.
They will recruit volunteers soon
.
Link to the paper: http://dx.
doi.
org/10.
1136/gutjnl-2021-325010 Hot Article Selection in 2020 1.
The cup is ready! A full paper cup of hot coffee, full of plastic particles.
.
.
2.
Scientists from the United States, Britain and Australia “Natural Medicine” further prove that the new coronavirus is a natural evolution product, or has two origins.
.
.
3.
NEJM: Intermittent fasting is right The impact of health, aging and disease 4.
Heal insomnia within one year! The study found that: to improve sleep, you may only need a heavy blanket.
5.
New Harvard study: Only 12 minutes of vigorous exercise can bring huge metabolic benefits to health.
6.
The first human intervention experiment: in nature.
"Feeling and rolling" for 28 days is enough to improve immunity.
7.
Junk food is "real rubbish"! It takes away telomere length and makes people grow old faster! 8.
Cell puzzle: you can really die if you don't sleep! But the lethal changes do not occur in the brain, but in the intestines.
.
.
9.
The super large-scale study of "Nature Communications": The level of iron in the blood is the key to health and aging! 10.
Unbelievable! Scientists reversed the "permanent" brain damage in animals overnight, and restored the old brain to a young state.
.
.
Diseases are closely related
.
Because the intestinal flora directly affects the balance between the pro-inflammatory response that triggers the disease and the anti-inflammatory response that fights the disease in the intestine
.
A healthy intestinal ecosystem must be in a balanced and mutually beneficial state; otherwise, it will exhibit various health problems
.
Nowadays, fecal bacteria transplantation (FMT), which is very mature, treats diseases by rebuilding the patient's intestinal flora, that is, pouring treated healthy human fecal fluid into the patient's intestine
.
In 1958, American doctors used fecal fluid to save infected critically ill patients.
This is the earliest case recorded in English literature
.
In China, similar "fecal bacteria transplantation" has a history of at least 2000 years
.
In recent years, the incidence of Clostridium difficile infection (CDI) has been increasing around the world, which is also an important reason why stool transplantation is widely used in clinical practice
.
Clostridium difficile is a gram-positive anaerobic bacillus widely distributed in human and animal intestines and the environment.
It is one of the most common hospital-acquired infections
.
Clostridium difficile is transmitted through the fecal-oral route, and the most important risk factors include antibiotic treatment, the elderly, and hospitalization
.
The clinical manifestations range from asymptomatic carriers, to varying degrees of diarrhea, to the most serious, life-threatening colitis, which eventually leads to death
.
In an article published on "Gut" on July 7, Beijing time, a research team led by Warsaw Medical University in Poland reported that two cases of recurrence of Clostridium difficile infection were "a blessing in disguise" after receiving fecal bacteria transplantation and were quickly cured Of his own new coronary pneumonia
.
The situation is like this: Recently, an 80-year-old male patient with various comorbidities such as pneumonia and a 19-year-old male patient with ulcerative colitis caused by immunosuppression in Poland received recurrence of severe Clostridium difficile infection.
Fecal bacteria transplantation
.
The results of the nasopharyngeal swab and stool test of the two patients before the operation were negative
.
However, to the surprise of the doctors, both patients tested positive for the new crown 7 days after the fecal bacteria transplantation
.
Although they are all at high risk of severe new coronary pneumonia, their symptoms are only mild, and they recovered quickly after only a few days of fever
.
Although the 19-year-old patient had a compromised immune system and did not even receive treatment for the new coronavirus infection, he only developed a fever of 39 degrees 15 hours after the fecal bacteria transplantation.
Subsequently, his body temperature did not exceed 36.
6 degrees.
C-reactive protein (CRP) ) And interleukin-6 (IL-6) levels returned to normal
.
In other words, the originally weak patient recovered on his own in a short period of time
.
The 80-year-old patient had his fever gone two days after receiving the fecal bacteria transplant, and he did not experience any worsening of pneumonia
.
One possible explanation is that fecal bacteria transplantation can alleviate more adverse consequences by affecting the interaction between the intestinal flora and the immune system
.
This has given researchers new ideas, and they will soon carry out relevant clinical trials to determine whether stool transplantation can really help patients recover from new coronary pneumonia
.
Researchers said that if fecal bacteria transplantation is not carried out, they really don't know how these two frail patients will fight the new coronary pneumonia.
Of course, it is difficult for them to determine the reason for the rapid recovery of these two cases
.
But this coincidence is enough to cause scientists to conduct in-depth investigations
.
As we all know, the intestinal flora of an individual is closely related to its immune system
.
Infection with the new coronavirus can cause obvious gastrointestinal disorders
.
Previously, researchers have proposed to use fecal transplantation to restore the patient's damaged intestinal flora, and may affect their immune response, including the respiratory system (gut-lung axis)
.
There are also some preliminary studies that show that fecal bacteria transplantation can restore the balance of intestinal flora to a certain extent after infection with the new coronavirus
.
However, no one has so far conducted in-depth research on whether this therapy is clinically effective or even safe
.
Fecal bacteria transplantation will be carefully screened when used as treatment to prevent patients from being infected, but there will always be some dangerous pathogens sneaking into it
.
In the current global pandemic, this possibility is even greater
.
Nevertheless, the researchers believe that the rapid recovery of these two cases in Poland is worthy of further exploration
.
Most patients infected with the new coronavirus will detect the virus in the stool within about 28 days, but in these two cases, the viral material disappeared from the stool sample much faster
.
The researchers said that the main conclusion drawn from these two cases is that fecal microbiota transplantation appears to be safe and effective in treating recurrent Clostridium difficile infections in patients with new coronary pneumonia
.
Fecal bacteria transplantation may shorten the clinical course of new coronary pneumonia
.
For example, fecal bacteria transplantation may strengthen the immune system of patients with new coronary pneumonia, triggering a series of molecular changes after certain bacteria colonization
.
Some previous studies have shown that the intestinal flora can affect the respiratory system (gut-lung axis), and in turn, it can also increase the lungs' resistance to new coronary pneumonia
.
The mechanism is unknown, the intestinal flora
.
To date, scientists still have little knowledge of how the intestinal flora affects the immune system, and how fecal bacteria transplantation ultimately facilitates this process
.
But the researchers said that this treatment may really help patients clear serious viral infections
.
Therefore, based on the experience of these two cases and other data that proves that the human gut microbes and the immune system are mutually renting, the team is conducting a clinical trial to evaluate the impact of fecal bacteria transplantation in the standard treatment of new coronary pneumonia on reducing the course of the disease
.
They will recruit volunteers soon
.
Link to the paper: http://dx.
doi.
org/10.
1136/gutjnl-2021-325010 Hot Article Selection in 2020 1.
The cup is ready! A full paper cup of hot coffee, full of plastic particles.
.
.
2.
Scientists from the United States, Britain and Australia “Natural Medicine” further prove that the new coronavirus is a natural evolution product, or has two origins.
.
.
3.
NEJM: Intermittent fasting is right The impact of health, aging and disease 4.
Heal insomnia within one year! The study found that: to improve sleep, you may only need a heavy blanket.
5.
New Harvard study: Only 12 minutes of vigorous exercise can bring huge metabolic benefits to health.
6.
The first human intervention experiment: in nature.
"Feeling and rolling" for 28 days is enough to improve immunity.
7.
Junk food is "real rubbish"! It takes away telomere length and makes people grow old faster! 8.
Cell puzzle: you can really die if you don't sleep! But the lethal changes do not occur in the brain, but in the intestines.
.
.
9.
The super large-scale study of "Nature Communications": The level of iron in the blood is the key to health and aging! 10.
Unbelievable! Scientists reversed the "permanent" brain damage in animals overnight, and restored the old brain to a young state.
.
.
