Tumor-promoting metabolites are found in human blood

BEIJING, Aug. 24 (Xinhua Zhang Mengran) -- Scientists have discovered a new link between aging and cancer progression, according to a new study published in the British journal Nature. This means that age-related metabolic disorders should play a role in increasing the risk of cancer in humans, and more importantly, the emergence of a new link between aging and cancer progression has laid the foundation for the emergence of new cancer therapies in the future.
this time, John Branis, a researcher at the Weill Cornell School of Medicine in the United States, and colleagues treated human cancer cell line in detail using the serums of 30 healthy donors aged 30 or under and the serums of 30 other donors aged 60 or older. The team found that cancer cells treated with the serum of older donors gained the ability to migrate, invade, survive and metascess. These cells also show elevated levels of protein associated with invasive cancers, as well as resistance to widely used chemotherapy drugs.
team analyzed metabolites in the serums of older and younger donors and found significantly higher concentrations of methyl propylene acid, a metabolite of protein and fat, in samples of older donors. Subsequent genetic analysis showed that higher concentrations of methamphetamine were associated with increased expression of the SOX4 gene, which contributes to tumor progression and metastasis, and higher levels of expression in invasive cancers. When SOX4 activity was blocked, methamphetamine did not increase the migration and invasiveness of cancer cells or resistance to chemotherapy drugs.
, a by-product of protein and fat metabolism in people aged 60 and over increases, which induces invasive characteristics such as drug resistance and metastasis of cancer cells. The researchers say the findings could suggest that age promotes higher levels of methyl propylene acid in the blood, allowing cancer cells to migrate, invade, survive and metastasy. The accumulation of methyl propylene acid represents a new link between aging and cancer progressy found in humans and is a potential target for new cancer therapies.
same time, a team at Washington University in St. Louis published new results in cancer treatment in the journal Cell, which found a way to improve the effectiveness of immunotherapy. A protein called TREM2 is expressed in large quantities in and around tumor cells. This suggests that when combined with blocking a protein therapy, the efficacy of immunotherapy drugs can be improved.