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    Home > Medical News > Medical World News > Tumor specific cytoplasmic targeting of Ras mutants can inhibit tumor growth

    Tumor specific cytoplasmic targeting of Ras mutants can inhibit tumor growth

    • Last Update: 2020-02-20
    • Source: Internet
    • Author: User
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    Because of its position in the cell, the oncogenic Ras mutant (rasmut) protein can not be contacted and targeted by conventional antibodies, so it is impossible to target this mutation and treat cancer by conventional antibody program Photo source: Science Advanced Recently, researchers from Asian University, chengjunguan University and orum therapeutics Inc of Korea cooperated to report an IgG antibody, inras37, targeting pan RAS The antibody can be internalized specifically by tumor cells into cytoplasm and directly act on various rasmut subtypes activated in cells, blocking the interaction with effector protein, thus inhibiting downstream signal transduction Injecting inras37 into mice with small rasmut xenograft tumor by systemic administration can produce strong antitumor activity, but this antibody has little effect on the downstream rasmut tumor with simultaneous PI3K mutation, which can be overcome by combining PI3K inhibitor The researchers found that the Yap1 protein in rasmut dependent colorectal tumors can be up-regulated and lead to drug resistance under the induction of inras37, so inras37 combined with Yap1 inhibitor has synergistic antitumor effect in vivo and in vitro All in all, this study provides a promising antibody targeting Ras mutant tumor and corresponding treatment strategy, breaking the phenomenon that the antibody can not target this mutation reference material:
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