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    Home > Biochemistry News > Biotechnology News > Tumor targeting: inducing apoptosis of cancer cells in T-cell acute lymphoblastic leukemia

    Tumor targeting: inducing apoptosis of cancer cells in T-cell acute lymphoblastic leukemia

    • Last Update: 2021-11-14
    • Source: Internet
    • Author: User
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    Acute lymphocytic leukemia (ALL) is a common childhood cancer


    Mitochondrial activated kinase MAP2K7 is a new target for anticancer drug therapy


    The only downstream substrate of MAP2K7 is JNK.


    The compound 5Z-7-oxozeaenol (5Z7O) can bind to the cysteine-218 position of MAP2K7, although it can also inhibit other kinases such as TAK1


    The Lacorazza research team at Baylor College of Medicine mentioned in their Oncotarget study summary: “We have provided proof-of-principle data to support the targeting of the MAP2K7 pathway in children’s T-ALL



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