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    Home > Medical News > Medical Research Articles > Twist Bioscience launches circulating tumor DNA reference standard, suitable for the development of liquid biopsy analysis

    Twist Bioscience launches circulating tumor DNA reference standard, suitable for the development of liquid biopsy analysis

    • Last Update: 2021-12-27
    • Source: Internet
    • Author: User
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    South San Francisco, California, USA--(Business Wire)--December 7, 2021--Twist Bioscience (NASDAQ: TWST) is a company that uses its silicon-based platform to provide high-quality synthetic DNA to help customers A successful company, the company announced the launch of the Twist cfDNA pan-cancer reference standard, a high-quality standardized control that can be used for the development and continuous monitoring of liquid biopsy tests to detect cancer through blood samples
    .

    Liquid biopsy testing is a promising and evolving field in clinical oncology, which relies on NGS-based circulating tumor DNA (ctDNA) analysis
    .
    Liquid biopsy analysis can accurately identify individual tumor variants in the presence of thousands of healthy cells

    .
    The most popular applications in the ctDNA field include early disease detection, personalized treatment, monitoring treatment response, and monitoring disease recurrence

    .
    The top priority is to develop and standardize these ultra-sensitive and accurate detection methods based on ctDNA to ensure that the analysis of the detection results can provide reliable information for clinical decision-making

    .

    Florian Battke, Head of Development Department of CeGaT GmbH, Germany, said: "With the increase in clinical validation experiments of liquid biopsy, a true ctDNA pan-cancer reference standard, rather than the few variants that are widely used today, will improve the ability of liquid biopsy to detect specific Accuracy in terms of oncogenes and mutations
    .
    The use of synthetic standards (such as Twist ctDNA standards) has a clear advantage because they are of high quality, very close to the characteristics of real samples, and there is no instability

    .
    "

    The Twist cfDNA pan-cancer reference standard material is composed of synthetically designed variant sequences and background DNA.
    The variant sequences mimic ctDNA, and the background DNA is derived from and highly mimics human cell-free DNA (cfDNA)

    .

    Researchers can use this reference standard to assist the development of liquid biopsy analysis to establish the limit of detection (LoD) for specific cancer variants, and use it as a control to track the quality of the NGS analysis process to ensure the fidelity of the analysis process Degrees
    .

    Twist cfDNA pan-cancer reference standards can be used in liquid biopsy procedures with Twist library preparation kit and Twist mechanical fragmentation kit to maximize efficacy, and provide a large number of different clinically relevant mutations, combined with first-class mutation synthesis methods, As well as excellent control over the frequency of specific target alleles, its form highly mimics the size distribution and fragmentation characteristics of cfDNA
    .
    In contrast, traditional reference standards have limitations in the number of variations and variations, and usually use DNA derived from cell lines, which may carry unwanted sequence variations and have variable fragment lengths

    .

    Dr.
    Emily M.
    Leproust, CEO and co-founder of Twist Bioscience, said: "Our SARS-CoV-2 positive control has now been successfully used in COVID-19 testing worldwide.
    On this basis, we believe in accurate standardization.
    The use of cancer controls in a validated workflow will be a game changer, enabling clinical insights to

    be confirmed from genetic information .
    Although specific controls for each test can be established, a powerful and precise control combination is used to detect the analysis Variability will be critical to the development and continuous monitoring of multiple liquid biopsy analyses

    .
    "

    When developing and validating analyses, the use of appropriate reference materials is essential to assess the complexity and biological content of DNA in liquid biopsy samples
    .
    The Twist ctDNA reference material contains more than 400 variants, including SNV, indels, fusions and structural variants, and more than 140 clinically relevant variants

    .
    All variants adopt a unique shingle design, which can accurately simulate the pattern of natural ctDNA

    .
    All these features make the Twist ctDNA reference a high-quality standard, suitable for ctDNA mutations that are designed to detect cancer liquid biopsy analysis

    .

    When demonstrating the limit of detection (LoD) of ultra-sensitive liquid biopsy analysis based on NGS, the use of an accurate quantitative ctDNA control is the key
    .
    Twist's silicon-based platform has an advantage in this regard.
    It clearly "writes" each variant of interest, thereby preventing any interference caused by contaminants caused by cell culture methods

    .
    Twist's ctDNA reference material has also been fully identified and quantified using industry standards and proprietary methods (NGS, ddPCR and fluorescence quantification)

    .

    About Twist Bioscience

    Twist Bioscience is a leading and fast-growing synthetic biology and genomics company that has developed a disruptive DNA synthesis platform to promote the industrialization of bioengineering
    .
    The core patented technology of the platform can create a new method of manufacturing synthetic DNA by "writing" DNA on a silicon chip

    .
    Twist is using its unique technology to manufacture more products based on synthetic DNA, including synthetic genes, next-generation sequencing (NGS) preparation tools, and antibody libraries for drug discovery and development

    .
    Twist is also seeking longer-term opportunities in the digital storage of DNA data and the exploration of biological agents

    .
    Twist's products have been widely used in many industries such as healthcare, industrial chemicals, agriculture, and academic research

    .

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