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    Home > Biochemistry News > Microbiology News > Two-Step Strategy for Alteration of Immunoglobulin Specificity by In Vitro Mutagenesis

    Two-Step Strategy for Alteration of Immunoglobulin Specificity by In Vitro Mutagenesis

    • Last Update: 2021-02-18
    • Source: Internet
    • Author: User
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    A two-step strategy for changing the specificity of antibodies (Abs) is presented, which we have used to change the specificity of an Ab from 11-deoxycortisol (11-DOC) to cortisol (CS). Two kinds of in vitro mutagenesis are utilized in this protocol: first, mutations are introduced at restricted positions in the complementarity-determining regions (CDRs) by site-directed mutagenesis; second, mutations are introduced into the entire V-coding regions by random mutagenesis.
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