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    Home > Active Ingredient News > Study of Nervous System > "Ultrafine particles" may carry clues to cancer, Alzheimer's disease and COVID-19

    "Ultrafine particles" may carry clues to cancer, Alzheimer's disease and COVID-19

    • Last Update: 2022-01-08
    • Source: Internet
    • Author: User
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    Researchers at Vanderbilt University Medical Center (Vanderbilt University Medical Center) have discovered a kind of nanoparticles released from cells, called "supermere", which contains a variety of cancers, cardiovascular diseases, Alzheimer's Zheimer's disease and even COVID-19 related enzymes, proteins and RNA


     

     

    News from Vanderbilt University Medical Center December 10

     

    The discovery, published in the journal Nature Cell Biology , is to understand the role of extracellular vesicles and nanoparticles in the transmission of important chemical "information" between cells (whether health or disease) Significant progress in the area


    Nature Cell Biology Extracellular vesicles and nanoparticles transmit important chemical "information" between cells

     

    The research was published in the journal Nature Cell Biology (latest impact factor: 28.


     

    Robert Coffey, MD, the senior author of the paper, said: "We have discovered some biomarkers and therapeutic targets in cancer and many other disease states, and these biomarkers and therapeutic targets may be the carriers of these super particles.


     

    Professor Robert Coffey

     

    Coffey is the Ingram Professor of Cancer Research and Professor of Medicine and Cell and Developmental Biology.


     

    In 2019, Dr.


    "Exosomes" extracellular vesicles

     

    That year, another colleague of Coffey, Dr.


    High-speed ultracentrifugation technology

     

    The members of the Supermere Discovery Team include (front row from left) Dr.


     

    In the current study, Zhang used "supernatant", which is the liquid that remains after exons are rotated into "particles," and rotates the liquid faster and longer


     

    The result is nanoparticles separated from the supernatant of the spinning exons, which the researchers named ultrafine particles


    They contain many substances that were previously thought to be in exosomes


    First, ultrafine particles carry most of the extracellular RNA released by cells,and these RNAs are present in the blood


    Extracellular RNA 

     

    Extracellular vesicles and granules

     

    Ultrafine particles are important carriers of TGFBI, which is a protein that promotes tumor progression in established tumors


    TGFBI may therefore be a useful marker in liquid biopsy of patients with colorectal cancer

     

    They also carry angiotensin-converting enzyme 2 (ACE2), a cell surface receptor that plays a role in cardiovascular disease and the target of the COVID-19 virus


    ACE2 carried by ultrafine particles can be used as a "bait" to bind with viruses to prevent infection

     

    Another potentially important cargo is APP, a beta-amyloid precursor protein that is involved in the development of Alzheimer's disease


    Ultrafine particles can cross the blood-brain barrier, which indicates that their analysis can improve the early diagnosis of diseases and may even target treatment

     

     

    Researchers from the University of Notre Dame pointed out in a review published with this paper: "Identified such a wealth of biologically active molecules.


    Potential as disease biomarkers

     

     

    Vanderbilt University founded in 1873

     

    University of Notre Dame founded in 1842

    references

    Source: Vanderbilt University Medical Center

    "Supermeres" may carry clues to cancer, Alzheimer's disease and COVID-19

    References:

    [1].
    Zhang, Q.
    , Jeppesen, DK, Higginbotham, JN et al.
    Supermeres are functional extracellular nanoparticles replete with disease biomarkers and therapeutic targets.
    Nat Cell Biol (2021).
    https://doi.
    org/10.
    1038/s41556 -021-00805-8

    [2].
    Clancy, JW, Boomgarden, AC & D'Souza-Schorey, C.
    Profiling and promise of supermeres.
    Nat Cell Biol (2021).
    https://doi.
    org/10.
    1038/s41556-021-00808-5



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