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    Home > Active Ingredient News > Endocrine System > Unexpectedly, TSH still has this relationship with eGFR...

    Unexpectedly, TSH still has this relationship with eGFR...

    • Last Update: 2021-04-18
    • Source: Internet
    • Author: User
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    Introduction: A study published at the 2021 American Dialysis Conference (March 5-7) found that the deterioration of renal function is correlated with the level of thyrotropin releasing hormone in patients.
    The higher the deterioration, the higher the degree of deterioration, The prevalence of hypothyroidism is usually higher.

     Study description This study aims to explore the prevalence of hypothyroidism in people with chronic kidney disease and whether there is a relationship between hypothyroidism and urine albumin-creatinine ratio and eGFR decline slope.

     Researchers used the electronic health database to identify 301 adults with chronic kidney disease who were treated at a kidney disease clinic in Quebec City, Canada.

    Chronic kidney disease is defined as having at least three examination records showing eGFR≤60ml/min/1.

     The diagnostic criteria for hypothyroidism is TSH>5uIU/L; the urine albumin-creatinine ratio at baseline>75 percentile (64mg/mmol) is defined as nephrotic-range proteinuria.

     Researchers observed that with the deterioration of renal function (eGFR grade), the prevalence of hypothyroidism gradually increased: ➤Patients with baseline eGFR 30-60mL/min/m2, the odds ratio of suffering from hypothyroidism was 2.
    32; ➤Baseline Patients with eGFR<30mL/min/m2 have an odds ratio of 8.
    65 for hypothyroidism.

     Further research showed that similar results were obtained in terms of urine albumin/creatinine ratio.

    Based on these results, researchers believe that TSH levels are correlated with eGFR slopes and proteinuria levels, that is, the higher the deterioration of renal function, the higher the TSH level.

     Summary There are many comorbidities associated with chronic kidney disease, such as hypertension, anemia, cardiovascular disease, and congestive heart failure.
    Hypothyroidism is also considered a comorbidity of chronic kidney disease.
    These patients are usually accompanied by metabolic syndrome.
    In patients with chronic kidney disease, the prevalence of hypothyroidism is about 3%-25%.

     Hypothyroidism is usually defined in the clinic by the level of thyrotropin releasing hormone.
    This study found that hypothyroidism diagnosed as a standard is more common in patients with worsening renal function (decreased eGFR) and in patients with proteinuria.

     Yimaitong compiled and compiled from: Iqbal S, et al.
    Thyroid-stimulating hormone and chronic kidney disease.
    Presented at: The Annual Dialysis Conference.
    March 5-7, 2021(virtual meeting).
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