University of London study: The brain grows and develops in the womb.

New research from University College London shows that blood vessels play an important role in stem cell division and differentiation, which can induce the brains of mice to grow and develop in the womb.
the study, funded by Wellcome, a British biomedical research fund, was published in the Proceedings of the National Academy of Sciences (PNAS).
study found that blood vessels in organisms can increase the number of neural stem cells.
important for various treatments that repair damaged or diseased nervous systems through stem cells.
in brain development, new nerve cells are produced by the differentiation of neural stem cells in specific regions.
stem cells in these regions differentiate into different nerve cells that divide at different times and frequencies.
, however, it is not clear what signals are being sent to regulate the process.
"We found that blood vessels are important in guiding the time and manner in which neural stem cells divide.
"Based on the important role of the brain stem in basic life activities such as breathing and heart rate, we tested the development of neural stem cells in mouse brain stem cells in the absence of the blood vessel protein NRP1," explains Mathew Tata of the Institute of Ophthalmology at University College London and author of the paper.
" preventing the growth of blood vessels in the area where nerve cells occur can interfere with the normal division of neurons and make neural stem cells incapauriable to divide.
, the neural stem cells in the brain stem will disappear and run out before they are finished growing.
this explains why mice lacking NRP1 have smaller brains.
study is the first to demonstrate that blood vessels not only affect brain development by transporting blood, but also play an important role in inducing signals of stem cell differentiation.
"It is generally believed that blood vessels play an important role in transporting oxygen and nutrients to the brain. "And this study shows that blood vessels regulate the activity of neural stem cells in the brain stem not only by providing oxygen or maintaining brain tissue health, but also provide important signals to guide neural stem cell differentiation long before neural stem cells are directed to differentiate into non-differentiated nerve cells," said Christiana Ruhrberg, lead author of the
paper and a researcher at University College London.
" Source: DeepTech DeepTech.