Unsaturated fatty acids can fight cancer? Cell sub-magazine exclusively reveals potential mechanism "Iron Death"

A recent study in Development Cell, based on the mechanism of "iron death", explored the relationship between cell iron, di-pyridine-linolenic acid (DGLA) and endogenous ether lipids in reproductive cells and human cancer cellsA potential treatment for cancer is proposed, that is, the use of DGLA-specific to induce iron death characteristics, the exogenous DGLA combined with small molecule iron-induced death inducer to kill cancer cellsdoi: 10.1016/j.devcel.2020.06.019 What is iron death? Ferroptosis, first proposed in 2012, is an iron-dependent form of non-apoptotic cell death characterized by a large accumulation of iron ions and lipid peroxidation during cell deathA large number of studies have found that iron death is closely related to neurological diseases, tumors, ischemic reperfusion injury diseases, kidney damage and iron metabolism diseasesiron death mechanism Iron death and fatty fats in an unsaturated fatty diet affect growth and development, steady state of the body, and certain diseases, but little is known about the link between fat and cell fat in the dietThe study found that DGLA can induce iron death and infertility of reproductive cells that cause beautiful hidden nematodes, and specifically induce iron death in human cancer cells, while supplementing endogenous ether lipids can avoid iron-dependent cell deathThe researchers co-treated nematodes with polyunsaturated fatty acids, antioxidant inhibitors ferrostatin-1 (Fer-1) and DGLA, and found that both iron death and apoptosis were activated, and that Fer-1 completely reversed the infertility of the Ced-3 mutants caused by DGLA, suggesting that DGLA could induce iron death in the reproductive cells of the beautiful hidden nematodeFer-1 regulates DGLA-induced germ cell death So, how does DGLA affect human cancer cells? In further experiments, the researchers found that DGLA was able to induce iron death by directly regulating the membrane phosphatidylationThe DGLA-induced death process is longer than the small molecule cystein blocker erastin, possibly because cells need to absorb fatty acids and donot it into cell phospholipids in order to function(A) cell death over time; (B) heat map showing that 6 hours after DGLA (500 or 250mM) and ethanol-controlled growth, the relative multiplier of various lipid fatty acid compositions, based on the relationship between polyniaic acids and iron death, proposed that DGLA combined with small molecule iron death inducer, can induce cancer cells and other sensitive cells in the body to cause iron death, which may be an effective way to treat cancer excavationScientists still have a long way to go in preventing and effectively treating cancerIn short, dietary polyunsaturated fatty acids are closely related to health and have important research valueAt the same time, physical health is not only related to a balanced diet, but also to quality sleep, regular exercise, regular physical examination and so onRelated: 1Lipid Dietarys Ferroptosis in Caenorhabditiselegans and Human Cancer CellsOmega-6 Fatty Acids and Risk for Cardiovascular DiseaseFerroptosis: an iron-dependent form of nonapoptotic cell death[4] Ferroptosis: A Regulated Cell Death Nexus Linking Metabolism, Redox Biology, and Disease.