Unsaturated fatty acids can fight cancer? Cell sub-magazine exclusively reveals potential mechanism "Iron Death"

As more and more people realize the importance of health care, most people are more likely to opt for unsaturated fats instead of them to reduce the risk of cardiovascular disease.
U.S. dietary guidelines recommend that if unsaturated fats are used instead of saturated fat, you consume less than 10 percent of your total calorie intake.
, a study in Development Cell looked at the relationship between cell iron, di-pyridine-linolenic acid (DGLA) and endogenous ether lipids in reproductive cells and human cancer cells based on the mechanism of "iron death".
and proposed a potential treatment for cancer, that is, the use of DGLA-specific induced iron death characteristics, the external DGLA combined with small molecule iron-induced death induction agents to kill cancer cells.
doi: 10.1016/j.devcel.2020.06.019 What is iron death? Ferroptosis, first proposed in 2012, is an iron-dependent form of non-apoptotic cell death characterized by a large accumulation of iron ions and lipid peroxidation during cell death.
a large number of studies have found that iron death is closely related to neurological diseases, tumors, ischemic reperfusion injury diseases, kidney damage and iron metabolism diseases.
iron death mechanism iron death and lipids in unsaturated fatty acid diets affect growth and development, steady state of the body, and certain diseases, little is known about the link between fat and cell fat in the diet.
the study found that DGLA can induce iron death and infertility in reproductive cells that cause beautiful hidden nematodes, and specifically induce iron death in human cancer cells, while supplementing endogenous ether lipids avoids iron-dependent cell death.
researchers used polyunsaturated fatty acids, antioxidant inhibitors ferrostatin-1 (Fer-1) and DGLA to co-process nematodes and found that both iron death and apoptosis were activated, while Fer-1 completely reversed the infertility of the Ced-3 mutants caused by DGLA, suggesting that DGLA could induce iron death in the reproductive cells of the beautiful hidden nematode.
Fer-1 regulates DGLA-induced reproductive cell death, how does DGLA affect human cancer cells? In further experiments, the researchers found that DGLA was able to induce iron death by directly regulating the membrane phosphatidylation.
the DGLA-induced death process is longer than the small molecule cystein blocker erastin, possibly because cells need to absorb fatty acids and donot it into cell phospholipids in order to function.
(A) cell death over time; (B) heat map showing that 6 hours after DGLA (500 or 250mM) growth with ethanol control, the relative multiplier variation of various lipid fatty acid compositions, based on the relationship between polynontic acids and iron death, proposes that DGLA combined with small molecule iron death inducer, can induce cancer cells and other sensitive cells in the body to cause iron death, which may be an effective treatment for cancer excavation.
scientists still have a long way to go in preventing and effectively treating cancer.
in general, dietary polyunsaturated fatty acids are closely related to health and have important research value.
at the same time, physical health is not only associated with a balanced diet, but also with quality sleep, regular exercise, regular physical examination and so on.
References: "1) Dietarys Ferroptosis in Caenorhabditiselegans and Human Cancer Cells. Omega-6 Fatty Acids and Risk for Cardiovascular Disease. Ferroptosis: an iron-dependent form of nonapoptotic cell death. [4] Ferroptosis: A Regulated Cell Death Nexus Linking Metabolism, Redox Biology, and Disease.