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    Home > Food News > Nutrition News > Up to 20% of people suffer from depression in their lifetime, which plays an important role in cognitive aging

    Up to 20% of people suffer from depression in their lifetime, which plays an important role in cognitive aging

    • Last Update: 2021-10-10
    • Source: Internet
    • Author: User
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    Although studies have shown that poor cardiovascular health can damage blood flow to the brain and increase the risk of dementia, a new study led by the University of California, San Francisco shows that poor mental health may also impair cognition Ability
    .

    This study provides more evidence for the link between depression and dementia, but although most studies point to the link between depression and life in old age, a study by the University of California, San Francisco showed that early adulthood Depression may cause cognitive decline after 10 years, and cause cognitive decline in the elderly
    .

    The study will be published in the "Journal of Alzheimer's Disease" on September 28, 2021
    .

    Researchers used innovative statistical methods to predict the average depressive symptom trajectory of approximately 15,000 participants between the ages of 20 and 89, dividing them into three life stages: old, middle-aged, and young
    .
    Then applying these predicted trajectories, it was found that for a group of approximately 6,000-year-old participants, the chance of cognitive impairment was 73% higher than the estimated depressive symptoms in early adulthood, and 43% higher than the estimated high depressive symptoms

    .

    These results were adjusted for differences in depression symptoms at other life stages, age, gender, race, education, body mass index, history of diabetes, and smoking status
    .
    For middle-aged depressive symptoms, the researchers found that it was related to cognitive impairment, but this was ruled out when they adjusted to depression in other stages of life

    .

    Excessive stress hormones may impair the ability to generate new memories

    The first author of the Department of Psychiatry and Behavioral Sciences at the University of California, San Francisco and the Weir Institute of Neuroscience and Master of Public Health Dr.
    Willa Brunnowitz said: "There are several mechanisms that explain how depression increases the risk of dementia.
    the

    .
    "" one of, the central system is overactive stress increases secretion of stress hormones glucocorticoids, resulting in damage to the hippocampus, while the hippocampus is the brain, tissue storage, and an important part of the new memory

    .
    "

    She said that other studies have linked depression to hippocampal atrophy, and one study showed that women shrink faster
    .

    In estimating depressive symptoms at each life stage, the researchers combined data from young participants with data from approximately 6,000 older participants and predicted the average trajectory
    .
    At the beginning of the study, the average age of these participants was 72.
    They lived at home and participated in the "Health Aging and Body Composition study" and the "Cardiovascular Health study"

    .
    They receive a follow-up survey once a year or every six months, which lasts up to 11 years

    .

    U-shaped curve increases the credibility of the predicted trajectory

    The author stated that although hypothetical values ​​are used, the longitudinal study of the entire life process has not been completed
    .
    They pointed out: "The inferred depressive symptom trajectory conforms to the u-shaped curve, similar to age-related trends in other studies

    .
    "

    The researchers used a tool called CESD-10 to screen participants for depression
    .
    CESD-10 is a 10-item questionnaire that assesses symptoms in the past week

    .
    Among the survey respondents, 13% of young people, 26% of middle-aged people, and 34% of old people have moderate or severe depressive symptoms

    .

    Approximately 1,277 participants were diagnosed with cognitive impairment after undergoing neuropsychological testing, evidence of global decline, documented use of dementia drugs, or hospitalization for dementia as the primary or secondary diagnosis
    .

    "Generally speaking, we found that the more severe the depressive symptoms, the lower the cognitive ability and the faster the decline," said Brunnowitz, who also belongs to the Department of Epidemiology and Biostatistics at the University of California, San Francisco
    .
    "It is estimated that older adults with moderate or severe depressive symptoms in early adulthood will experience cognitive decline over a period of more than 10 years

    .
    "

    Kristine Yaffe, MD, senior author in the Department of Psychiatry and Behavioral Sciences, Department of Epidemiology and Biostatistics at the University of California, San Francisco, said that as many as 20% of people suffer from depression throughout their lives.
    The role in aging is very important

    .
    "Further work is needed to confirm these findings, but at the same time, we should screen and treat depression from multiple causes

    .
    "



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