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Recently, the international academic journal Genomics, Proteomics and Bioinformatics published online the latest advances in the study of ringRNA by Yang Li Research Group of the Shanghai Institute of Life Sciences (Institute of Nutrition and Health) of the Chinese Academy of Sciences and the German MapU Computational Biology Research Group on the research of circular RNA" "CIRCpedia v2: Anupdate Database for The Comprehensive Rna And Resing Of E.
the study released an upgraded version of the ring RNA database CIRCpedia v2 by integrating the analysis of multi-species ring RNA data.
an upgraded version of the ring RNA database CIRCpeida v2 included the results of more than 180 samples of ring RNA calculations from 6 species (including humans, mice, rats, zebrafish, fruit flies and nematodes).
obtained 262,782 ring RNA molecules, including 73,972 variable reverse splicing events, primarily through CIRCexplorer2 and MapSplice calculation process statistics.
users can obtain diverse information such as ring RNA genome coordinates, expression levels, variable reverse shears, and human mouse conservatism through the retrieval and download module, graphically view the specific expression patterns of ring RNA on the genome by browsing the module, and compare the ring RNA in different samples through the new online analysis tool.
this upgraded version of the ring RNA database website provides a comprehensive and comprehensive platform for circular RNA research, and provides data support and theoretical basis for in-depth research on ring RNA function.
Yang Li Research Group has long been engaged in RNA histology research, revealing the key role of anembedded complementary pairing sequence on ring RNA expression through a collaborative research system (Zhang et al.Cell 2014; Zhang et al., Cell Rep 2016; show that competitive pairingbetweens between complementary pairing sequences of different shun-sequential inclusions can lead to variable reverse splicing of ring RNA, resulting in multiple ring RNA molecules from one gene site (Zhang et al., GenomeRes 2016); One of the main causes of high expression in humans (Dong et al., RNABiol 2017); the discovery of a new mechanism for the regulation and function of trans-acting protein factor NF90/NF110 on the regulation and function of ring RNA expression (Li et al., Mol Cell 2017); and a number of invited reviews, which systematically summarize the latest advances in the processing of ring RNA generation and its potential biological function (Yang, WIREs RNA 2015; Chen and Yang, Trends Cell Biol 2017; Li et al., Mol Cell 2018).
the research was conducted under yang Li's guidance by Dong Rui (now a postdoctoral fellow at Harvard University), Ma Xukai and Li Guowei, graduate students of Shubo Lian, and supported by the State Foundation Committee and the Chinese Academy of Sciences.
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