Urbanized environments are more likely to cause immune disorders in young children and a higher risk of asthma and allergies, the study found

Asthma is caused by bacteria, viruses and a variety of allergens caused by chronic airway inflammation, will cause shortness of breath, chest tightness, cough and other symptoms, most of the disease at an early age, and most asthma patients have allergic rhinitis or other allergic phenomena, seriously threatening the public's health.
study found that urban children were at higher risk of allergic diseases such as asthma, rhinitis and eczema than children living in rural areas.
there is a hypothesis that exposure to more animals and microorganisms in rural life can promote the maturation of the infant microbiome, while insufficient exposure to beneficial microorganisms in urban areas can lead to infant immune disorders.
but whether urbanization will have an impact remains to be seen.
Recently, researchers from the University of Copenhagen in Denmark published a study in journal of Allergy and Clinical Immunology entitled Urbanized microbiota in infants, immune constitution and later risk of atopic diseases, which found that infants living in urban and rural areas have significantly different respiratory and gut microbiome structures, while changes in the infant microbiome associated with the urban environment may increase the risk of asthma and respiratory allergies, which are associated with affecting the immune system.
To test whether urbanization is associated with microbiome composition and early immune function in infants, and whether these factors affect the risk of developing asthma and allergic diseases later in life, the researchers followed nearly 700 infants in the Copenhagen Prospective Study Of Childhood Asthma, 314 of whom lived in rural areas and 372 in urban areas.
collected and analyzed respiratory and gut microbiotics at different points in the year before the age of one, and made forward-looking diagnoses of asthma, eczema and allergic rhinitis at age 6, as well as covariances such as pet ownership, breastfeeding time, number of sibling children, mode of delivery, and genetic diseases.
The diagnosis of asthma and allergic symptoms showed that children who lived in urban areas for one year had a significantly higher risk of asthma, eczema and allergic rhinitis, with prevalence rates of 26.6 per cent, 34.6 per cent and 8.6 per cent, respectively, compared to children living in rural areas.
addition, the rate of air allergy and food allergy among rural children was significantly lower than that of urban children.
and adjusting covariables, the prevalence of asthma and air allergen sensitivity in urban infants increased significantly along the urbanization gradient.
the prevalence of asthma and allergic diseases in urban and rural infants was analyzed on the respiratory tract and intestinal bacteria of infants, and it was found that the respiratory bacteria and intestinal virlocy of urban and rural infants varied significantly at different points in time.
urban infants, the relative abundance of respiratory microorganisms such as Verongococcal genus, twin genus, and streptococcus and intestinal microorganisms such as Virococcal genus, while the relative abundance of respiratory microorganisms such as Viroxycobacteria genus, sly bacteria genus and Catamella genus and intestinal microorganisms such as Bifidobacteria is higher.
in addition, the relative concentrations of immunological media in urban and rural infants were different, with relatively high levels of human lecierle interlesin IL-12p70 and il-10 with anti-inflammatory properties in rural infants.
The relative concentration differences of respiratory tract and whole body immune media in urban and rural infants analyzed the correlation between microbiomes, immune media concentration and disease risk associated with urban and rural infants, and found that respiratory bacterial structure and immune factors (including specific coercion factors, cytokines) associated with living environment showed a significant correlation at 1 month of age, and urbanized respiratory bacteri and intestinal bacillus structures were also significantly associated with increased risk of asthma, eczema and gas-sensitive disease.
The prospective cohort study, which measures the living environment and the risk of asthma and allergic diseases at age 6, suggests that urban living conditions affect the infant's microbiome, which in turn affects early immune function and increases the risk of inflammatory diseases such as asthma, eczema and gas-based allergenicity in young children.
also reminds us not to over-clean the children's life environmental protection, moderate contact is naturally conducive to the development of resistance! (）