Uremic patients can take vitamin D to reduce inflammation

Chronic kidney disease (CKD) is characterized by a loss of renal function and an increase in uremic toxins in the serum, which can lead to inflammation Recently, researchers such as Barbosa de Oliveira Brito of the University of Sao Paulo in Brazil found that 25 hydroxyvitamin D has anti-inflammatory effect in uremia The study was published in the journal scientific reports Chronic kidney disease is characterized by the loss of glomerular filtration rate, resulting in the accumulation of toxic substances in the serum, known as uremic toxin, which eventually develops into uremia, and uremic toxin can induce inflammation in patients with chronic kidney disease Uremic patients usually need dialysis to support their daily life However, despite the progress of dialysis technology, all toxins cannot be removed Therefore, uremic toxins are still present in dialysis patients Some studies have shown that uremic toxins are directly related to inflammation and cardiovascular disease, which is the main cause of death in patients with chronic kidney disease Uremic toxins mainly produce proinflammatory cytokines such as TNF - α, IL-6 and MCP-1 by monocytes, which cause immune activation Although these proinflammatory cytokines can enhance the host's defense, their over secretion can lead to inflammation Uremic toxins may also induce the activation of Toll like receptor (TLR) and produce a variety of inflammatory mediators In addition to cytokines, 25 hydroxyvitamin D is also considered as an inflammatory marker, involved in innate and adaptive immunity The researchers confirmed that uremia is associated with inflammation, which is caused by elevated levels of cytokines and reactive oxygen species In addition, the serum of uremic patients is similar to that of chronic kidney disease patients, showing the result of low 25 hydroxyvitamin D Studies by Barbosa de Oliveira Brito et al also showed that 25 hydroxyvitamin D reduced TLR-4, MCP-1 and cathepsin inhibitor in uremic patients In conclusion, the findings provide evidence that vitamin D plays a role in the prevention of inflammation through monocyte mediated Reference source: doi.org/10.1038/s41598-019-56874-1 denigui statement: this point of view only represents the author, not the position of yaozhi.com, welcome to exchange and supplement in the message area; if you need to reprint, please be sure to indicate the author and source of the article.