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Original title: U.S. Media: Study Suggests Amyloid Plaque May Not Cause Alzheimer's disease
U.S. Media says scientists have known for decades that Alzheimer's disease is always associated with the accumulation of amyloid between brain cells. This has long been the mainstream theory driving research into the disease. But a new study suggests that this response may be wrong.
The researchers said they found that Alzheimer's patients experienced early memory and thinking decline, often before, rather than after, amyloid plaques appeared in the brain.
"Our study found subtle differences in the participants' thinking and memory, and based on brain scans, the accumulation of amyloid proteins in the brains of these subjects accelerated over time, suggesting that amyloid may not appear in the early stages of Alzheimer's disease development," study author Kelsey Thomas explained in a journal news release. "
Most of the research exploring treatments for Alzheimer's disease has focused on amyloid protein, but based on our findings, the focus needs to shift to other possible targets," said Thomas, who is working on the study at the U.S. Veterans Administration's San Diego Health Care Center. At
, the researchers also performed high-tech brain scans on participants and then scanned them annually for the next four years for signs of amyloid plaque build-up, The Associated Press reported.
researchers found that people with mild cognitive impairment did not experience amyloid protein build-up as quickly as those with normal thinking and memory.
, however, slight cognitive impairment can be accompanied by changes in other parts of the brain, such as the accelerated thinning of the olfactory cortite in the brain and the atrophy of the brain's hippocupine body. These two brain regions are critical to memory.
the development of Alzheimer's disease may have another culprit, thomas said.
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