Use and function of pharmaceutical-grade betacyclodextrin

Use and function of pharmaceutical-grade betacyclodextrin is widely used in the separation of organic compounds and for organic synthesis, and is also used as pharmaceutical excipients, food additives, etc
.
Natural cyclodextrins and modified cyclodextrins are prepared into clathrates with some non-biocompatible drug molecules
.
It not only increases the biocompatibility of the drug, but also plays a role
in slow release.
Properties: β-Cyclodextrin is a non-reducing cyclic polysaccharide
composed of seven D-glucopyranolyl groups combined with α-1,4-bonds.
White or almost white crystalline solid or crystalline powder, practically odorless, slightly sweet.

This product is slightly soluble in water and almost insoluble
in methanol, ethanol and acetone.
Efficacy: 1.
Odor molecules in food can be absorbed to form an envelope, thereby masking or driving away bad odors in food, especially health foods with peculiar smells; 2.
Unstable ingredients in food can be absorbed to form claddles for stable release, especially flavors and fragrances; 3.
It can be used as a deodorant, thickener and emulsifier in dairy products; 4.
It can significantly increase the price period
of food.
【Content determination】Determined
by high performance liquid chromatography (General 0512).
chromatographic conditions and system suitability test with octadecylsilane bonded silica gel as filler; Water-methanol (93:7) was used as the mobile phase; Measured by a refractive index detector, the detector temperature is 40 °C, take an appropriate amount of alpha cyclodextrin reference substance, betacyclic dextrin reference substance and gamma cyclodextrin reference substance, add water to dissolve and quantitatively dilute to make a mixed solution containing 0.
5mg of each of the above reference substances per 1ml, as a suitable solution
for the system.
Take 50μl into the liquid chromatograph, record the chromatogram, and the resolution of gamma-cyclodextrin peak and alpha cyclodextrin peak should meet the requirements; The tailing factor of each chromatographic peak should be between 0.
8~2.
0, and the number of theoretical plates of each chromatographic peak should not be less than 1500.

Determination method take about 250mg of this product, weigh it accurately, put it in a 25ml measuring flask, add water to dissolve and dilute to the scale, shake well, take 5ml accurately, put it in a 50ml measuring flask, dilute it to the scale with water, shake well, take 50μl of precision and inject it into the liquid chromatograph, and record the chromatogram; In addition, about 25mg of betacyclic dextrin reference substance was taken, accurately weighed, placed in a 25ml measuring flask, dissolved with water and diluted to the scale, shaken well, and determined
by the same method.
According to the external standard method, the peak area is calculated, that is, obtained
.
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