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*It is only for medical professionals to read for reference.
How can patients with diarrhea effectively stop diarrhea? Bacillus licheniformis is a high-quality clinical choice
.
Diarrhea disease is one of the global public health problems.
Antibiotics, as commonly used drugs for diarrhea, can be effective in antibacterial and anti-inflammatory.
However, a large number of broad-spectrum antibiotic treatments lead to imbalance of intestinal flora, especially Clostridium difficile and methicillin-resistant.
A large number of pathogenic bacteria such as Staphylococcus aureus and Klebsiella multiply and release various endotoxins to cause inflammation of the intestinal mucosa
.
Causes of diarrhea There are 1.
7 billion cases of diarrhea worldwide each year, of which 2.
2 million patients die from severe diarrhea
.
Most patients with acute diarrhea have a short course of disease and a low rate of consultation, which is only 30%-40%
.
The mild one is a self-limiting process, and the severe one can cause death due to severe dehydration, poisoning and shock [1]
.
The causes of diarrhea are mainly divided into: ① infectious diarrhea; ② diarrhea caused by non-infectious inflammation; ③ diarrhea caused by tumor; ④ intestinal malabsorption; ⑤ functional diarrhea; ⑥ drug-induced diarrhea
.
The cause of diarrhea is often not a single mechanism, but a combination of multiple links
.
The pathological manifestations of diarrhea are intestinal inflammation and edema, etc.
According to the course of the disease, it is divided into two types: acute diarrhea and chronic diarrhea: acute diarrhea such as dysentery and enteritis is often accompanied by serious imbalance of intestinal flora, resident bacteria are significantly reduced, and external attacks The abnormal increase of bacteria; chronic diarrhea such as irritable bowel syndrome, acute post-acute dysentery diarrhea, malabsorption syndrome, the number of major intestinal bacteria decreases, chronic diarrhea and intestinal flora imbalance are mutually cause and effect [2,3]
.
The impact of gut microecology on diarrhea The gut microecosystem is the most important and complex microecosystem of the human body.
There are about 1014 microorganisms, accounting for 78% of the total microbial biomass of the human body, encoding about 3.
3 million genes, which are human genes.
The number is about 150 times [4,5]
.
The normal intestinal flora forms a large and complex micro-ecosystem, which has important physiological functions such as maintaining the normal histological and anatomical structure of the host, barrier flora, vitamin synthesis and material metabolism [6]
.
The homeostasis of the normal intestinal flora is a process of dynamic balance.
If it is disturbed by external pathogenic factors, it is prone to disorder, leading to disease [7]
.
The principle of treatment of diarrhea is to remove and treat the cause, prevent and correct dehydration, nutritional support, and rational use of drugs [8]
.
At present, the traditional treatment method for diarrhea is to use antibiotics, but after long-term non-standard antibiotic application, most sensitive bacteria and normal flora are suppressed or killed, while drug-resistant bacteria can multiply due to the selective effect of antibiotics.
Therefore, Long-term extensive use of broad-spectrum antibiotics is a common cause of flora imbalance
.
Antibiotic-related diarrhea (AAD) is a common complication of the clinical application of antibiotics.
The use of probiotics while using antibiotics can significantly reduce the incidence of AAD and reduce the degree of AAD [7]
.
Probiotics are normal intestinal parasitic bacteria, which can adjust the intestinal flora, restore the normal microecological balance, resist the colonization of pathogenic bacteria, and have a good preventive and therapeutic effect on acute and chronic diarrhea and intestinal flora imbalance caused by antibiotics[ 3]
.
Prevention and management of diarrhea: Bacillus licheniformis is a high-quality choice Bacillus licheniformis is a facultative anaerobic bacteria.
Under aerobic conditions, it can quickly consume free oxygen in the ecological environment and produce a powerful biological oxygen deprivation effect, resulting in intestinal The hypoxic environment promotes the growth of anaerobic bacteria and plays a role in adjusting the imbalance of intestinal flora [9,10]
.
Bacillus licheniformis can effectively regulate the distribution of the intestinal flora of the body, and significantly improve the clinical efficacy, quality of life and survival rate of patients with diarrhea
.
Studies have reported that Bacillus licheniformis can increase the proportion of beneficial intestinal bacteria such as Lactobacillus and Bifidobacterium, while Enterobacter and Enterococcus are significantly reduced (P<0.
05) [11]
.
A number of studies have confirmed that Bacillus licheniformis is effective in treating patients with diarrhea, and the KPS score was significantly higher than before treatment (P<0.
05) [11,12]
.
Antibiotics can destroy the normal intestinal flora, and long-term medication can cause secondary diarrhea, especially for people with low autoimmune function
.
Bacillus licheniformis acts on the intestinal tract, activates the relevant immune tissues on the intestinal mucosa, promotes the growth of lymphatic tissues, and improves the body's immune capacity [10]
.
For patients treated with antibiotics, Bacillus licheniformis reduces the incidence of AAD and can effectively improve the therapeutic effect of AAD
.
A randomized parallel controlled study included elderly patients receiving antibiotic treatment.
The intervention group was given Bacillus licheniformis to prevent AAD.
The results showed that the incidence of AAD in the intervention group was significantly lower (13.
6% VS 27.
4%, P=0.
01) [13]
.
Another study reported that the treatment of pediatric patients with secondary diarrhea with Bacillus licheniformis capsules combined with montmorillonite powder has a higher overall effective rate (98% vs 83%) and shorter antidiarrheal time than montmorillonite powder alone.
, There are fewer bowel movements in a week, and the length of hospital stay is shortened by 2 days (P<0.
05) [14]
.
During the growth and metabolism of Bacillus licheniformis, it can produce a variety of antibacterial active substances, such as gramicidin, polymyxin, subtilisin, nystatin, etc.
, which can effectively inhibit pathogenic bacteria and improve intestinal colonization tolerance [8]
.
Unlike Bifidobacterium, Lactobacillus and Bacillus subtilis, which are sensitive to all antibiotics, Bacillus licheniformis is not sensitive to erythromycin, gentamicin, chloramphenicol and first and second generation cephalosporins, and can be the same as most antibiotics.
Service [15]
.
In addition, Bifidobacterium probiotics need to be stored at low temperature, while Bacillus licheniformis has a natural spore structure that can be stored at room temperature, and can maintain activity during transportation, use and storage.
At the same time, the spore structure is acid and salt resistant, and is not easily affected by gastric acid, bile and Digestive enzymes are inactivated [16], so it is convenient to store in the hospital (pharmaceutical department, warehouse) and carry it with the patient outside the hospital
.
In summary, Bacillus licheniformis can regulate the intestinal flora by exerting an oxygen-absorptive effect, effectively antagonize pathogenic bacteria, and enhance the body's immunity
.
For patients with diarrhea, Bacillus licheniformis can shorten the time of antidiarrhea, the length of hospitalization, reduce the frequency of bowel movements, improve the treatment effect and the satisfaction of family members, and it has high safety and is a high-quality clinical choice
.
Jingchangle Bacillus licheniformis capsules are rich in 500 million live bacteria, exert multiple functions, and have been recognized by the majority of clinicians.
Its characteristics and advantages are summarized as follows: 1,500 million live bacteria, stronger oxygen deprivation, and more pronounced antidiarrheal: Contains 500 million live bacteria, has a biological oxygen absorption effect, supports the growth of anaerobic bacteria, and has a significant antidiarrheal effect; 2.
The only bacteria cures bacteria and actively antagonizes a variety of pathogenic bacteria: produces a variety of antibacterial active substances, which is effective for golden yellow grapes.
Cocci, Candida albicans and other pathogenic bacteria have obvious antagonistic effects; 3.
Safer and more convenient, free of conditional pathogenic bacteria: Excreted from the body 10 days after stopping the drug in excess of the normal number, safe and non-toxic and side effects; 4.
Store at room temperature, can be linked Use of antibiotics: The spore structure is acid and salt resistant, not easily inactivated by gastric acid, bile and digestive enzymes, and is not sensitive to erythromycin, gentamicin, chloramphenicol and first and second generation cephalosporins
.
References: [1] Miao Xiaohui, Zhang Wenhong, Weng Xinhua.
Expert consensus on diagnosis and treatment of adult acute infectious diarrhea [2] Fang Hesong, Duan Shucheng, Dong Zongqi, etc.
Diagnosis and treatment plan of Chinese diarrhea[J].
Journal of Clinical Pediatrics,1994,12 (3):148.
[3]McFarland LV.
Meta-analysis of probiotics for the prevention of an-tibiotic associated diarrhea and the treatment of Clostridium difficile disease[J].
Am J Gastroenterol,2006,101(4):812- 822.
[4]Qin J,Li R,Raes J,et al.
A human gut microbial gene catalogue established by metagenomics sequencing[J].
Nature,2010,464(7285):59-65.
[5]Clemente JC, Ursell LK,Parfrey LW.
The impact of the gut microbiota on human health:an integrative view[J].
Cell,2012,148(6):1258-1270.
[6],.
Normal human intestinal flora The research progress of [J], Chinese Journal of Microecology, August 2010, Vol.
22, No.
8.
[7] Lu Wenquan, Liu Huanhuan, et al.
Comparative analysis of the efficacy of different flora transplantation regimens in the treatment of diarrhea models[J], World Update Digest of Medical Information, 2019, Volume 19, Issue 42.
[8] Luo Hesheng, Zhou Zhongyin.
Reasonable application of diarrhea treatment drugs[J].
Chinese Journal of Practical Internal Medicine, Volume 29, Issue 5, May 2009 [9] Tang Juan , Zhang Yi, Li Leilei, et al.
Research progress in the application of Bacillus licheniformis[J].
Hubei Agricultural Sciences, 2008, 47(3): 351～354.
[10] Wu Tielin, Bai Ri Peng, et al.
20386 strains of Bacillus licheniformis Study on characteristics and ecological preparations[J].
Chinese Journal of Microecology, Vol.
2, No.
2, 1990 [11] Zhu Liang, Yu Qiuguo.
The effect of live Bacillus licheniformis capsules on the imbalance of intestinal flora caused by GP chemotherapy in inoperable non-small cell lung cancer[J], Journal of Hunan Normal University (Medical Edition), 2018, 15 (3) [12] Zhang Dongmei, Chen Ai, etc.
.
Prospective study of probiotics in the treatment of chemotherapy-related diarrhea[J].
Journal of Clinical Digestive Diseases 2013 Vol.
25 No.
1[13],.
Probiotics preparations prevent antibiotic-related diarrhea in elderly patients[J].
Stomach Enterology 2010 Vol.
15 No.
3 [14] Wang Junyao et al.
Chinese Journal of Hospital Pharmacy.
2003, (07): 419.
[15] Ritu Sareen, Uwe T Bornscheuer, Prashant Mishra.
Biotechnol Lett.
2005, 27( 23-24):1901-7.
[16]Chen Zhiyong,Li Nahe.
Observation on the effect of live Bacillus licheniformis capsules in the treatment of secondary diarrhea in children with bronchial pneumonia[J].
Fujian Medical Journal, Vol.
42 No.
4, August 2020 Disclaimer: This content is only for Chinese medical and health professionals, and aims to provide scientific information to and only to medical and health professionals for personal learning and reference purposes
.
If you are not a medical and health professional, please do not participate or spread
.
-End-This article is only used to provide scientific information to medical professionals and does not represent the platform's position
.
How can patients with diarrhea effectively stop diarrhea? Bacillus licheniformis is a high-quality clinical choice
.
Diarrhea disease is one of the global public health problems.
Antibiotics, as commonly used drugs for diarrhea, can be effective in antibacterial and anti-inflammatory.
However, a large number of broad-spectrum antibiotic treatments lead to imbalance of intestinal flora, especially Clostridium difficile and methicillin-resistant.
A large number of pathogenic bacteria such as Staphylococcus aureus and Klebsiella multiply and release various endotoxins to cause inflammation of the intestinal mucosa
.
Causes of diarrhea There are 1.
7 billion cases of diarrhea worldwide each year, of which 2.
2 million patients die from severe diarrhea
.
Most patients with acute diarrhea have a short course of disease and a low rate of consultation, which is only 30%-40%
.
The mild one is a self-limiting process, and the severe one can cause death due to severe dehydration, poisoning and shock [1]
.
The causes of diarrhea are mainly divided into: ① infectious diarrhea; ② diarrhea caused by non-infectious inflammation; ③ diarrhea caused by tumor; ④ intestinal malabsorption; ⑤ functional diarrhea; ⑥ drug-induced diarrhea
.
The cause of diarrhea is often not a single mechanism, but a combination of multiple links
.
The pathological manifestations of diarrhea are intestinal inflammation and edema, etc.
According to the course of the disease, it is divided into two types: acute diarrhea and chronic diarrhea: acute diarrhea such as dysentery and enteritis is often accompanied by serious imbalance of intestinal flora, resident bacteria are significantly reduced, and external attacks The abnormal increase of bacteria; chronic diarrhea such as irritable bowel syndrome, acute post-acute dysentery diarrhea, malabsorption syndrome, the number of major intestinal bacteria decreases, chronic diarrhea and intestinal flora imbalance are mutually cause and effect [2,3]
.
The impact of gut microecology on diarrhea The gut microecosystem is the most important and complex microecosystem of the human body.
There are about 1014 microorganisms, accounting for 78% of the total microbial biomass of the human body, encoding about 3.
3 million genes, which are human genes.
The number is about 150 times [4,5]
.
The normal intestinal flora forms a large and complex micro-ecosystem, which has important physiological functions such as maintaining the normal histological and anatomical structure of the host, barrier flora, vitamin synthesis and material metabolism [6]
.
The homeostasis of the normal intestinal flora is a process of dynamic balance.
If it is disturbed by external pathogenic factors, it is prone to disorder, leading to disease [7]
.
The principle of treatment of diarrhea is to remove and treat the cause, prevent and correct dehydration, nutritional support, and rational use of drugs [8]
.
At present, the traditional treatment method for diarrhea is to use antibiotics, but after long-term non-standard antibiotic application, most sensitive bacteria and normal flora are suppressed or killed, while drug-resistant bacteria can multiply due to the selective effect of antibiotics.
Therefore, Long-term extensive use of broad-spectrum antibiotics is a common cause of flora imbalance
.
Antibiotic-related diarrhea (AAD) is a common complication of the clinical application of antibiotics.
The use of probiotics while using antibiotics can significantly reduce the incidence of AAD and reduce the degree of AAD [7]
.
Probiotics are normal intestinal parasitic bacteria, which can adjust the intestinal flora, restore the normal microecological balance, resist the colonization of pathogenic bacteria, and have a good preventive and therapeutic effect on acute and chronic diarrhea and intestinal flora imbalance caused by antibiotics[ 3]
.
Prevention and management of diarrhea: Bacillus licheniformis is a high-quality choice Bacillus licheniformis is a facultative anaerobic bacteria.
Under aerobic conditions, it can quickly consume free oxygen in the ecological environment and produce a powerful biological oxygen deprivation effect, resulting in intestinal The hypoxic environment promotes the growth of anaerobic bacteria and plays a role in adjusting the imbalance of intestinal flora [9,10]
.
Bacillus licheniformis can effectively regulate the distribution of the intestinal flora of the body, and significantly improve the clinical efficacy, quality of life and survival rate of patients with diarrhea
.
Studies have reported that Bacillus licheniformis can increase the proportion of beneficial intestinal bacteria such as Lactobacillus and Bifidobacterium, while Enterobacter and Enterococcus are significantly reduced (P<0.
05) [11]
.
A number of studies have confirmed that Bacillus licheniformis is effective in treating patients with diarrhea, and the KPS score was significantly higher than before treatment (P<0.
05) [11,12]
.
Antibiotics can destroy the normal intestinal flora, and long-term medication can cause secondary diarrhea, especially for people with low autoimmune function
.
Bacillus licheniformis acts on the intestinal tract, activates the relevant immune tissues on the intestinal mucosa, promotes the growth of lymphatic tissues, and improves the body's immune capacity [10]
.
For patients treated with antibiotics, Bacillus licheniformis reduces the incidence of AAD and can effectively improve the therapeutic effect of AAD
.
A randomized parallel controlled study included elderly patients receiving antibiotic treatment.
The intervention group was given Bacillus licheniformis to prevent AAD.
The results showed that the incidence of AAD in the intervention group was significantly lower (13.
6% VS 27.
4%, P=0.
01) [13]
.
Another study reported that the treatment of pediatric patients with secondary diarrhea with Bacillus licheniformis capsules combined with montmorillonite powder has a higher overall effective rate (98% vs 83%) and shorter antidiarrheal time than montmorillonite powder alone.
, There are fewer bowel movements in a week, and the length of hospital stay is shortened by 2 days (P<0.
05) [14]
.
During the growth and metabolism of Bacillus licheniformis, it can produce a variety of antibacterial active substances, such as gramicidin, polymyxin, subtilisin, nystatin, etc.
, which can effectively inhibit pathogenic bacteria and improve intestinal colonization tolerance [8]
.
Unlike Bifidobacterium, Lactobacillus and Bacillus subtilis, which are sensitive to all antibiotics, Bacillus licheniformis is not sensitive to erythromycin, gentamicin, chloramphenicol and first and second generation cephalosporins, and can be the same as most antibiotics.
Service [15]
.
In addition, Bifidobacterium probiotics need to be stored at low temperature, while Bacillus licheniformis has a natural spore structure that can be stored at room temperature, and can maintain activity during transportation, use and storage.
At the same time, the spore structure is acid and salt resistant, and is not easily affected by gastric acid, bile and Digestive enzymes are inactivated [16], so it is convenient to store in the hospital (pharmaceutical department, warehouse) and carry it with the patient outside the hospital
.
In summary, Bacillus licheniformis can regulate the intestinal flora by exerting an oxygen-absorptive effect, effectively antagonize pathogenic bacteria, and enhance the body's immunity
.
For patients with diarrhea, Bacillus licheniformis can shorten the time of antidiarrhea, the length of hospitalization, reduce the frequency of bowel movements, improve the treatment effect and the satisfaction of family members, and it has high safety and is a high-quality clinical choice
.
Jingchangle Bacillus licheniformis capsules are rich in 500 million live bacteria, exert multiple functions, and have been recognized by the majority of clinicians.
Its characteristics and advantages are summarized as follows: 1,500 million live bacteria, stronger oxygen deprivation, and more pronounced antidiarrheal: Contains 500 million live bacteria, has a biological oxygen absorption effect, supports the growth of anaerobic bacteria, and has a significant antidiarrheal effect; 2.
The only bacteria cures bacteria and actively antagonizes a variety of pathogenic bacteria: produces a variety of antibacterial active substances, which is effective for golden yellow grapes.
Cocci, Candida albicans and other pathogenic bacteria have obvious antagonistic effects; 3.
Safer and more convenient, free of conditional pathogenic bacteria: Excreted from the body 10 days after stopping the drug in excess of the normal number, safe and non-toxic and side effects; 4.
Store at room temperature, can be linked Use of antibiotics: The spore structure is acid and salt resistant, not easily inactivated by gastric acid, bile and digestive enzymes, and is not sensitive to erythromycin, gentamicin, chloramphenicol and first and second generation cephalosporins
.
References: [1] Miao Xiaohui, Zhang Wenhong, Weng Xinhua.
Expert consensus on diagnosis and treatment of adult acute infectious diarrhea [2] Fang Hesong, Duan Shucheng, Dong Zongqi, etc.
Diagnosis and treatment plan of Chinese diarrhea[J].
Journal of Clinical Pediatrics,1994,12 (3):148.
[3]McFarland LV.
Meta-analysis of probiotics for the prevention of an-tibiotic associated diarrhea and the treatment of Clostridium difficile disease[J].
Am J Gastroenterol,2006,101(4):812- 822.
[4]Qin J,Li R,Raes J,et al.
A human gut microbial gene catalogue established by metagenomics sequencing[J].
Nature,2010,464(7285):59-65.
[5]Clemente JC, Ursell LK,Parfrey LW.
The impact of the gut microbiota on human health:an integrative view[J].
Cell,2012,148(6):1258-1270.
[6],.
Normal human intestinal flora The research progress of [J], Chinese Journal of Microecology, August 2010, Vol.
22, No.
8.
[7] Lu Wenquan, Liu Huanhuan, et al.
Comparative analysis of the efficacy of different flora transplantation regimens in the treatment of diarrhea models[J], World Update Digest of Medical Information, 2019, Volume 19, Issue 42.
[8] Luo Hesheng, Zhou Zhongyin.
Reasonable application of diarrhea treatment drugs[J].
Chinese Journal of Practical Internal Medicine, Volume 29, Issue 5, May 2009 [9] Tang Juan , Zhang Yi, Li Leilei, et al.
Research progress in the application of Bacillus licheniformis[J].
Hubei Agricultural Sciences, 2008, 47(3): 351～354.
[10] Wu Tielin, Bai Ri Peng, et al.
20386 strains of Bacillus licheniformis Study on characteristics and ecological preparations[J].
Chinese Journal of Microecology, Vol.
2, No.
2, 1990 [11] Zhu Liang, Yu Qiuguo.
The effect of live Bacillus licheniformis capsules on the imbalance of intestinal flora caused by GP chemotherapy in inoperable non-small cell lung cancer[J], Journal of Hunan Normal University (Medical Edition), 2018, 15 (3) [12] Zhang Dongmei, Chen Ai, etc.
.
Prospective study of probiotics in the treatment of chemotherapy-related diarrhea[J].
Journal of Clinical Digestive Diseases 2013 Vol.
25 No.
1[13],.
Probiotics preparations prevent antibiotic-related diarrhea in elderly patients[J].
Stomach Enterology 2010 Vol.
15 No.
3 [14] Wang Junyao et al.
Chinese Journal of Hospital Pharmacy.
2003, (07): 419.
[15] Ritu Sareen, Uwe T Bornscheuer, Prashant Mishra.
Biotechnol Lett.
2005, 27( 23-24):1901-7.
[16]Chen Zhiyong,Li Nahe.
Observation on the effect of live Bacillus licheniformis capsules in the treatment of secondary diarrhea in children with bronchial pneumonia[J].
Fujian Medical Journal, Vol.
42 No.
4, August 2020 Disclaimer: This content is only for Chinese medical and health professionals, and aims to provide scientific information to and only to medical and health professionals for personal learning and reference purposes
.
If you are not a medical and health professional, please do not participate or spread
.
-End-This article is only used to provide scientific information to medical professionals and does not represent the platform's position
.
