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In order to understand gene regulation more comprehensively, a group of researchers developed a technique that can map almost all possible regulatory switches in the genome
This research was published in the paper " The native cistrome and sequence motif families of the maize ear.
The regulatory switch is controlled by transcription factors
A team led by Dr.
"By creating an accurate map of corn regulatory sites and transcription factors, gene expression can be optimized by targeting these sites," said the first author of the paper and FSU alumnus Savannah Savardet who is now studying at Baylor College of Medicine.
The authors write that they used MOA-seq as a proof of concept on the ear of corn, which was able to define the cis-body of 145,000 MOA footprints (MFs)
Buss said: "We found high-precision light switches in the proof-of-concept test organization of corn ears
The author writes that this genome-wide analysis "not only defines the chromatin landscape, but the key is to be able to fully discover and map sequence motifs under the small footprints of about 30 bp, thereby generating candidate TF occupancy maps
Buss said: "The understanding of genome structure should help focus on genome editing and accelerate larger-scale applied research, such as guiding research in precision agriculture and medicine
