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Use of Arginine Analogs as Inhibitors of Nitric Oxide Synthase in Rat-Aortic Rings

 Last Update: 2020-12-05
 Source: Internet
 Author: User

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nitric oxide test

3 pi 4

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Nitric oxide synthases (NOS) are expressed constitutively in vascular endothelial cells (eNOS;
1
) and can be induced in vascular smooth muscle following stimulation with cytokines and endotoxin (inducible (i) NOS; for review,
seeref.2
). The discovery and characterization of inhibitors of NOS (
3
,
4
) led to the elucidation of the biological significance of NO synthesis within the vessel wall.

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