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    Home > Biochemistry News > Biotechnology News > Using CRISPR gene editing to improve cell therapy Vertex reaches a $1.2 billion collaboration

    Using CRISPR gene editing to improve cell therapy Vertex reaches a $1.2 billion collaboration

    • Last Update: 2021-09-13
    • Source: Internet
    • Author: User
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    On August 24, Vertex Pharmaceuticals and Arbor Biotechnologies announced that the two parties will launch a new collaboration to use Arbor's proprietary CRISPR gene editing technology to enhance the development of innovative cell therapies for the treatment of serious diseases
    .

    Arbor was co-founded by renowned scholar Dr.
    Feng Zhang with the aim of discovering new gene-editing proteins and developing "tailor-made" nuclease therapy for diseases based on these proteins
    .
    The company has discovered more than 60 nuclease families and more than 70 CRISPR transposases (transposases), which are 6 times and 30 times the number published in the literature
    .

    The new agreement between Arbor and Vertex builds on the partnership established between the two parties in 2018
    .
    According to this new cooperation agreement, Vertex will obtain the right to use Arbor's technology to research and develop ex vivo engineered cell therapies to develop fully differentiated, insulin-producing low-immune islet cells for the treatment of type 1 diabetes; and research and development A new generation method for the treatment of diseases such as sickle cell disease and beta thalassemia
    .

    Under the terms of the agreement, Arbor will receive an advance payment and is eligible for potential milestone payments of up to $1.
    2 billion
    .
    In addition, Vertex will also pay tiered royalties for future net sales of any products that may result from this cooperation
    .

    Reference materials:

    [1] Vertex and Arbor Biotechnologies Establish New Partnership to Develop Novel ex vivo Engineered Cell Therapies.
    Retrieved 2021-08-24, from https:// /en/Vertex-and-Arbor-Biotechnologies-Establish-New-Partnership-to-Develop-Novel-ex-vivo-Engineered-Cell-Therapies.
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    (The original text has been deleted)

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