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    Home > Medical News > Medical World News > Using explosives detection for drug development Oxford University start-up is about to "break the tradition"

    Using explosives detection for drug development Oxford University start-up is about to "break the tradition"

    • Last Update: 2020-02-19
    • Source: Internet
    • Author: User
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    Editor's note: mass spectrometry (mass spectrometry) is an analytical technique for ionizing chemicals and ranking them according to their mass charge ratio (mass charge ratio) Recently, omass therapeutics, a start-up company derived from the University of Oxford, announced the completion of 27.5 million pounds a round of expansion financing, bringing its total a round financing amount to 41.5 million pounds (about 54 million US dollars) Unlike traditional drug development methods based on cell analysis, the company uses natural mass spectrometry technology to develop small molecule drugs for the treatment of immune and genetic diseases Speaking of mass spectrometry, you may feel strange, but it is often used in daily work such as the determination of iodine in drinking water The technology was also used to detect explosives at airports, the press release said Most of the current therapies modify cell signaling by targeting membrane proteins, which can be obtained on the cell surface The development strategy of mass spectrometry adopted by omass can provide a "high definition" view for the understanding of membrane protein biology Specifically, the technology platform can not only detect the lead compound combined with the target compound, but also regulate the formation and function of the compound by measuring the mass change These methods were used to find membrane target drugs including GPCRs At present, this technology is in the leading position in the field of natural mass spectrometry It allows the study of protein targets in the folded natural state, so as to retain any related non covalent interaction This captures drug interactions and their impact on downstream interactions necessary to determine function In this way, the technology can directly observe Pharmacology (binding and function) with unprecedented resolution provided by biophysical methods such as mass spectrometry Photo source: omass therapeutics website At present, the company has three unpublished development projects for GPCRs, focusing on the treatment of genetically defined immune dysfunction patients We hope omass can make full use of its innovative technology to develop new drugs for membrane proteins! reference material:
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