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    Home > Biochemistry News > Biotechnology News > Using focused ultrasound to control the activity of CAR-T cells in solid tumors can reduce off-target effects

    Using focused ultrasound to control the activity of CAR-T cells in solid tumors can reduce off-target effects

    • Last Update: 2021-08-27
    • Source: Internet
    • Author: User
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    In a new study, researchers have developed a cancer immunotherapy that combines ultrasound with cancer-killing immune cells to destroy malignant tumors while preserving normal tissues


    This research solves a long-term problem in the field of cancer immunotherapy: how to make chimeric antigen receptor (CAR) T cell (CAR-T) therapy to treat solid tumors safely and effectively


    CAR-T cell therapy is a promising new method for the treatment of cancer


    CAR-T cell therapy is very effective in treating some blood cancers and lymphomas, but it has no effect on solid tumors


    To solve this problem, these authors used standard CAR-T cells and redesigned them so that they only express CAR protein when ultrasonic energy is applied


    The cancer immunotherapy developed by these authors involves injecting redesigned CAR-T cells into tumors in mice, and then placing a small ultrasound transducer on the skin area above the tumor to activate CAR-T cells


    The in vitro function of CAR-T cells targeting prostate-specific membrane antigen (PSMA) induced by FUS series ultrasound.


    These authors tested their CAR-T cells with standard CAR-T cells


    However, this research is still in its early stages


    Note: The original text has been deleted

    Reference materials:

    Yiqian Wu et al.


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