echemi logo
Product
  • Product
  • Supplier
  • Inquiry
    Home > Medical News > Latest Medical News > Using gene editing technology to create a model of family dog autism, Shino Valley creatures have won key scientific topics at the national level

    Using gene editing technology to create a model of family dog autism, Shino Valley creatures have won key scientific topics at the national level

    • Last Update: 2020-06-26
    • Source: Internet
    • Author: User
    Search more information of high quality chemicals, good prices and reliable suppliers, visit www.echemi.com
    Guide: New trends in the leadership of gene editing technologyJust past World Autism Day 2020, Beijing Shino Valley Biotech Co., Ltdreleased an experimental video of the Autism Family Dog ModelPreviously, the Chino Valley creature successfully gave birth to the world's first gene-edited autistic model dog in March 2018video, wild-type Biggs actively interact with people and hear strangers calling names, while Shank3 (synaptic dense area stent protein gene) gene editor canine autistic models are eye-to-eye, interactive, like to be alone, and occasionally go crazyZhao Jianping, deputy general manager of shino Valley Biology at, told Arterial Network that behavioral abnormalities and repetitive stereotypes in Shank3 gene editing dogs are the clinical core symptoms of autism, "As an animal model, to simulate the pathogenesis and clinical characteristics of patients, in addition to the need to knock on the SHANK3 gene, the more important is that behavioral patterns and social interactions should be compatible with the patient." This is the first time that humans have used canine gene editing and cloning techniques to build social and emotional-related genetic mutants that reveal the biological basis of social and emotionalit is understood that in December 2019, The Institute of Genetics and Developmental Biology of the Chinese Academy of Sciences, the Institute of Biophysics of the Chinese Academy of Sciences, the Kunming Institute of Zoology of the Chinese Academy of Sciences, and the five units of Peking University jointly applied for the "Social and Emotional Biological Foundation and Transformation Research" special project in the "Key Scientific Issues of Transformative Technology" in the Ministry of Science and Technologydogs are one of the longest-running human animals, and the earliest canbe be traced back to the Neolithic period more than 10,000 years agoUsing domestic dogs as model animals, social and emotional and cognitive function research can better reveal the genetic and neurobiological mechanisms of human social and emotional, and may lead to future breakthroughs in drug development for cognitive and mental illnessthe world's leading provider of animal genetic technology
    since autism was first diagnosed in 1943, scientists have been working to identify deeper pathogenesis of the diseaseBy testing the genes of a large sample of autistic people, the researchers found that SHANK3 has a strong association with autismSHANK3 is one of the most studied genes for autism, and the main clinical symptoms of autism spectrum are reduced muscle tone, developmental delay, language loss or delay, social disorder, and even intellectual disabilityBy analyzing the whole genome sequence of domestic dogs, the researchers found that the Shank 3 gene structure in domestic dogs was similar to that of humansSo the Chino Valley creature sedited the gene for the family dogMrZhao Jianping told Arterial Network that the company currently has Shank3 21 exon fragment deletion, 5 to 21 outer onsp large fragment snippets deleted F0 generation and a large number of different gene types of hybrid F1 generationThrough phenotype analysis, mutant dogs showed different degrees of abnormal motor ability, repetitive stereotypes, social abnormalities of dogs/dogs and human/canines, cognitive impairment and other clinical symptoms of autismfounded in 2012,Shino Valley Bio is a national high-tech enterprise located in Changping Science and Technology Park in BeijingAs a domestic enterprise engaged in the commercialization of animal genetic technology, Shino Valley has created two major technology platforms for animal gene editing and somatic cell cloning, and has developed a new field of global gene editing dog disease models, developing a new generation of model animalsShino Valley creatures have bred the world's first gene-edited atherosclerosis disease model dog "Apple", the world's first gene-edited clone dog "Dragon Dragon", the world's first autistic disease model dog, the world's first point mutation GCK diabetes model dog, the world's first LCA congenital black-and-white model dog, the first cloned police dog "Kunxun", the first cloned cat "garlic" and otherin fact, dogs have a long history of research as experimental animals for drug development, are internationally recognized standard experimental animals and have contributed to several Nobel Prizes in physiology or medicineMrZhao Jianping pointed out that in the long-term survival process with human beings, similar growth environment and diet structure, long-term convergence and evolution, the development of many similar characteristics with humans, often more obedient, the experiment is also higher degree of cooperation"The dogs that used more in the experiment were big dogs, which were similar to people in histology, anatomy, structural science, and played an important role in drug metabolism and toxicology researchSince its inception, Shino Valley Bio has been developing a series of gene editors who simulate human clinical diseases, has formed a model of animals covering brain science, cardiovascular, metabolic diseases, rare diseases and other directions, breeding to the F2 generation, for a number of domestic scientific research institutions, medical institutions, biopharmaceutical enterprises to provide support disease pathogenesis research, drug effectiveness evaluation, new drug research and development experiments, non-drug treatment effectiveness test and evaluation of model animalscompared with other types of model animals, such as mice and non-human primates, domestic dogs have a wealth of social and emotional, especially with human sinter-species social and emotional, high coordination, fast reproduction, easy genetic operationAt the same time, dogs as a common pet, with a relatively perfect medical system, image, B super, biochemical and other testing can provide adequate medical means for the research and application of model dogs, is the study of a variety of common human diseases of the ideal model animalsGene editing the dog disease model, using genetic engineering methods to genetically edit the canine genome, the symptoms of the disease is primary symptoms, phenotype duration is long, and has hereditability, can more comprehensively and truthfully simulate human diseaseAccording to Mr Zhao Jianping, at present, the Shino Valley creatures mainly through mature model sales and commissioned custom development of two ways to export model animals For the cultivation of relatively mature model animals, such as systemic atherosclerosis family dog model, autistic family dog model, mainly by order sales directly to the user product, and for the research team's new project direction, the new project direction, the model animals need further development, The innovator biological by customized development of the way to complete delivery At the same time, given that many research teams do not have experimental platforms and sites for large animals, the company provides model animal-based experimental services for large animals Through many years of operation, Thehigo Valley biological accumulation of rich experience and research capabilities, with a number of domestic and foreign universities, research institutes, pharmaceutical companies to establish a stable cooperative relationship life science and technology are booming, model animals are in great demand
    in the field of life science research, experimental research requires four basic elements, namely experimental animals, equipment, information and reagents Experimental animals, also known as model animals, are an indispensable carrier for life science research, according to statistics, the journal Nature Medicine in 2008 published all the papers, about 86% of the use of experimental animals With the rapid development of gene editing technology, people began to try to use gene modification methods to obtain a variety of gene deletion sororns and gene knock-in experimental animals at present, the rapid development of scientific research and achievement transformation in the field of life science in China has led to a rapid increase in demand for the model animal industry as a support and service industry, with an annual growth rate of more than 20% In particular, the rapid development of genetic technology, the need for more accurate simulation of human gene defect syllitas of gene editing model animals are being released explosively With the continuous and rapid development of the global life sciences industry, the model animal industry has become not only a sub-industry of the life sciences industry, as a major driving force in biotechnology, medicine, pharmaceutical and other industries In recent years, research institutions and research teams from all over the world have invested heavily in life science research , citing the National Institutes of Health (NIH), one of the largest life sciences research units in the United States, the National Institutes of Health received $32.3 billion in research funding from the U.S federal government in 2016, an increase of about $2 billion, or 6 percent, from 2015 According to NIH, the average daily experimental animal stock of the top 25 federally funded institutions in the United States has increased significantly over the past 15 years, from about 74,600 between 1997 and 2003 to about 128,900 between 2008 and 2012, an increase of 73% in China, the 13th Five-Year Plan for National Economic and Social Development and the Decision of the State Council on Accelerated Cultivation and Development of Strategic Emerging Industries all regard the life science industry as one of the new strategic industries In recent years, investment in life science research has been increasing Biomedical research alone has grown from about $2 billion in 2007 to about $8.4 billion in 2012, an average annual increase of 33 percent, creating a huge demand for model and model-based animals to conduct animal experiments, according to the New England Journal of Medicine (NEJM) gene editing technology is the most popular and fastest-growing application field in biotechnology, and one of the most direct and effective methods for studying gene function in the genomic age Dogs are standard model animals in biomedical research, and gene-edited disease model dogs are ideal large animal models for the study of human brain science, cardiovascular disease, metabolic diseases, rare diseases and tumors Mr Zhao Jianping said that as a new generation of model animals, the gene editing dog model in the life science basic and transformation application research, is expected to open up new research direction and drive new industries, in order to improve the efficiency of drug research and development, drug screening, drug metabolism, drug efficacy evaluation and other provide strong support and efficient help
    This article is an English version of an article which is originally in the Chinese language on echemi.com and is provided for information purposes only. This website makes no representation or warranty of any kind, either expressed or implied, as to the accuracy, completeness ownership or reliability of the article or any translations thereof. If you have any concerns or complaints relating to the article, please send an email, providing a detailed description of the concern or complaint, to service@echemi.com. A staff member will contact you within 5 working days. Once verified, infringing content will be removed immediately.

    Contact Us

    The source of this page with content of products and services is from Internet, which doesn't represent ECHEMI's opinion. If you have any queries, please write to service@echemi.com. It will be replied within 5 days.

    Moreover, if you find any instances of plagiarism from the page, please send email to service@echemi.com with relevant evidence.