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Recently , the research group of Professor Long Dong from University of Science and Technology of China has made important progress in the research of oncogene protein Ras microsecond timescale dynamics and druggable " cryptic state " .
inactive Ras" was published in the Proceedings of the National Academy of Sciences of the United States of America .
How to develop small-molecule compounds that can specifically bind to and regulate disease-related proteins is the core issue in targeted drug research .
The well-known oncogene protein Ras, as a key signal transduction protein in cells , has been confirmed to be closely related to the occurrence of about 30% of human malignant tumors .
In previous work, Professor Long Dong's research group has combined a variety of nuclear magnetic resonance relaxation experimental methods to quantitatively capture the local conformational movement of inactive Ras on the microsecond time scale , and proposed a Ras "hidden state" as the design target .
possibility
The research work was funded by the Ministry of Science and Technology, the Fund Committee and the Anhui Provincial Project .
Retrospective testing of a representative implicit pocket conformation and ligand-binding capacity of inactive Ras .
Paper link: https://doi.
org/10.
1073/pnas.
2024725118
(Hefei National Research Center for Microscale Matter Science, Department of Life Science and Medicine, Department of Scientific Research)
