Vaccine with "cupping"!

Using methods similar to cupping, an international team has developed a new method of delivering DNA molecules to skin cells

After entering the 21st century, nucleic acid therapy has developed rapidly, and has shown great potential in the treatment of various diseases and the development of vaccines

In the new crown epidemic, vaccines based on this principle have already shined

In nucleic acid therapy, a key step is transfection, that is, allowing DNA or RNA fragments to pass through the cell membrane to enter the nucleus or cytoplasm of the host cell, respectively

If no additional protection mechanism is adopted, even if DNA or RNA fragments are injected into the host’s tissues, it is difficult for them to enter the host cell and can only be rapidly degraded in the extracellular matrix

Is there a way to transport DNA fragments more safely and conveniently? Recently, a research team from Rutgers University in the United States and GeneOne Life Science, a South Korean biopharmaceutical company, used a technique similar to cupping to successfully achieve this goal

Cupping occupies a place in traditional medicine in China, the Middle East, and ancient Greece

Based on this idea, the research team tested the effect of using this method to deliver a new coronavirus DNA vaccine candidate in a mouse experiment

▲Schematic diagram of experimental device (picture source: reference [1])

The results of the experiment are amazing: the DNA fragments in the vaccine successfully entered the skin cells of the mice and caused a strong immune response-in a set of control experiments, the immune response induced by this was directly when the DNA vaccine was injected subcutaneously 100 times

▲After direct injection and a combined suction process, changes in the concentration of neocoronavirus antibodies in mice (picture source: reference [1])

Professor Lin Hao pointed out that this method provides a simple, cheap, and easy-to-scale platform for laboratory and clinical research and development of nucleic acid-based therapies and vaccines

Once the above advantages can be reflected in practical applications, then the advantages of the DNA vaccine itself will also appear

Due to its remarkable effect in mouse experiments, human clinical trials of this new technology with GeneOne Life Science's GLDS-5310 new crown DNA vaccine are underway

Note: The original text has been deleted

Reference materials:

[1] Emran O.

[2] Combining ancient and modern medicine, scientists use cupping to deliver COVID-19 vaccine in lab tests.