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    Home > Chemicals Industry > Chemical Technology > Vanillic acid

    Vanillic acid

    • Last Update: 2022-06-06
    • Source: Internet
    • Author: User
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    Vanillic acid

    Vanillic acid

    [Synonym] 4-Hydroxy-3-methoxybenzoic acid, 4-Hydroxy-3-methoxybenzoic acid

    【Structural formula】

     

    【Molecular formula and molecular weight】C 8 H 8 O 4 ;168.
    15

    [Source] Scrophulariaceae plant Picrorhiza scrophularii flora.
    Pennell dry rhizome
    .

    【Properties】White crystals
    .

    This product is easily soluble in methanol and acetone
    .

    【Purity Check】

    TLC

    1.
    Thin layer plate silica gel GF254 plate

    Developing solvent hexane - ether - acetic acid (5: 5: 0.
    1)

    Check under UV lamp (254nm)

    2.
    Thin layer plate silica gel G plate

    Developing agent toluene- ethyl acetate - glacial acetic acid (8:4:0.
    03)

    After checking the color development of 10% sulfuric acid ethanol solution, check under visible light

    High performance liquid chromatography

    Column HypersilC 18 , 5um (4.
    6mm×150mm)

    Mobile phase Methanol 0.
    02% phosphoric acid solution (9:91), 1ml / min

    Detection wavelength 260nm

    【Structural identification】290,259,217,205
    .

    3485 (-OH), 1682 (C=O), 1597, 1523, 1433, 1203, 1111, 1028, 918, 881, 766
    .

    MS m/z: 168[M] + , 153, 151, 125, 108, 97
    .

    1 H-NMR (DMSO) δ: 12.
    45 (1H, br, -COOH), 9.
    80 (1H, s, -OH), 7.
    45 (1H, d, J=8.
    0 Hz, H-6), 7.
    44 (1H, s , H-2), 6.
    83 (1H, d, J=8.
    0 Hz, H-5), 3.
    79 (3H, s, -OCH 3 )
    .

    13 C-NMR (DMSO) δ: 121.
    6(C-1), 115.
    0(C-2), 147.
    1(C-3), 151.
    1(C-4), 112.
    0(C-5), 123.
    5(C-6) , 167.
    0 (-COOH), 55.
    6 (-OCH 3 )
    .

    【Storage】Dry and airtight
    .

     

     

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