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A naturally occurring carnivore bacteria can work with the immune system to remove the multi-drug-resistant bacteria Schleseps in zebrafish.
researchers recently published the results in the journal Current Biology.
this is the first time vibrio phage has been successfully used in antimicrobial treatment, marking an important step towards defeating drug-resistant bacteria or superbugs.
infection can cause diarrhoea, causing 160 million cases each year, of which more than 1 million die.
, the resistance of the bacteria has become more severe.
, a team of researchers at Imperial College London and the University of Nottingham decided to fight the drug-resistant Shigella with Vibrio.
when the researchers put the two bacteria together in the lab, Vibrio reduced the number of Shigella by thousands of times.
to test Vibrio's ability to control drug-resistant Gloranian-negative infections, they infected zebrafish cubs with Shigella M90T, while at the same time infecting them with Vibrio.
results, zebrafish cubs had a 60% live rate.
in the control group, zebrafish cubs that were not infected with Vibrio had a survival rate of only 25% on the third day of infection.
Serge Mostowy, of Imperial College London, who was involved in the study, said: "This study does give people a glimpse of the unique and wonderful nature of Vibrio, which shows a synergy with the immune system that, if it exists in the body long enough, can kill bacteria before they are naturally removed."
" Liz Sockett of the University of Nottingham points out that vibrio aggression breaks down Shigella cells and stimulates white blood cells, which, by their double effect on Shigella, eventually lead to an increase in the survival rate of zebrafish cubs.
, however, the researchers also said there appeared to be a "vicious battle" between carnivores and host white blood cells, which eventually led to the surviving of the immune zebrafish.
in fact, Vibrio can kill a variety of Gloranian-negative bacteria, such as E. coli and salmonella, in nature.
also found that it can reduce the bacteria in the stomach of chickens.
of course, it is not known whether Vibrio can succeed in humans.
but researchers say it's a positive sign and the key to fighting a drug-resistant crisis.
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