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    Home > Active Ingredient News > Endocrine System > Vitamin C supplementation can lower uric acid? These 10 fruits must be understood!

    Vitamin C supplementation can lower uric acid? These 10 fruits must be understood!

    • Last Update: 2021-03-27
    • Source: Internet
    • Author: User
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    *Only for medical professionals' reference, eating these fruits can cure gout! Gouty arthritis is a common metabolic disease.
    Most patients have repeated joint swelling and pain, and most patients can get long-term relief after continuous lowering of uric acid [1-2].

    The prevalence of hyperuricemia and gout is increasing worldwide, especially in high-income and economic developing countries.

    The existing analysis shows that the prevalence of adult hyperuricemia is about 20%, the prevalence of adolescent hyperuricemia is 14%, and the prevalence of gout is 2.
    6% [3-4].

    This means that almost one in five people has a high uric acid level.

    01 More than drugs can lower uric acid.
    It usually takes 1 year for the urate crystals in the joints to dissolve completely.
    Tophi takes longer, usually several years.

    The key to preventing the recurrence of gouty arthritis is to keep the blood uric acid level up to the standard, but not all gout patients need to be treated with uric acid-lowering drugs.
    National guidelines do not recommend starting uric acid-lowering treatment for patients with first attacks, because the drug benefit risk ratio is not high .

    Since vitamin C was discovered by Hungarian biochemist Albert Szent-Györgyi in 1932, its role in regulating various biological processes has been extensively studied.

    Vitamin C is a water-soluble vitamin.
    It has many physiological functions such as antioxidant, promoting collagen synthesis, improving immunity, relieving toxicity, preventing atherosclerosis, and playing important physiological functions in the body.

    It was clinically discovered in the 1980s that vitamin C has the effects of lowering uric acid and reducing the incidence of gout in the general population.
    It is economical and has no toxic side effects.

    02 Studies have confirmed that vitamin C can lower uric acid.
    It turns out that vitamin C can also lower uric acid? Do not believe? Let's see what studies can confirm this. A randomized controlled trial involving 184 non-smoking patients with hyperuricemia [5] compared vitamin C with placebo.
    The results showed that the vitamin C group received oral vitamin C, 500 mg/d, for 2 months, and blood uric acid levels.
    Decrease by 0.
    5mg/L, and the blood uric acid level of the placebo group decreased by 0.
    09mg/L.

    The effect of vitamin C in lowering uric acid was significantly better than that of the placebo group.

    In addition, vitamin C can also increase the glomerular filtration rate of patients.

    No obvious side effects of vitamin C have been reported.

    Ma Ling et al.
    [6] found that the serum vitamin C level of patients with hyperuricemia was significantly reduced.
    The reduction of vitamin C may be related to its consumption as an antioxidant and in the process of scavenging excessive free radicals.
    Vitamin C can prevent or reduce due to oxygen Free radicals and nitro free radicals play an important antioxidant effect in the treatment of diseases caused by free radicals.

    Vitamin C can promote uric acid excretion, increase uric acid excretion fraction, reduce cell damage induced by oxidative stress, and indirectly reduce blood uric acid levels.

    Jia Shaodan et al.
    [7] also showed through research that oxidative stress also exists in hyperuricemia.

    Vitamin C plays an important antioxidant effect in preventing or reducing the treatment of diseases caused by oxygen free radicals and nitro free radicals.

    03Why vitamin C can lower uric acid The mechanism by which vitamin C lowers blood uric acid levels is not completely clear, and may include the following mechanisms: 1.
    Vitamin C can lower blood uric acid levels mainly because it can promote uric acid excretion, which may compete with it Sexual inhibition of the proximal convoluted tubule anion transporter [8], at the tip of the proximal convoluted tubule brush border, vitamin C can specifically bind to urate transporter 1 and sodium-dependent anion cotransporter SLC5A8/A12 uric acid reabsorption Site.

    2.
    Vitamin C is also known as L-ascorbic acid, which can enhance the dissolving ability of uric acid accumulated in the tissue and facilitate the excretion of uric acid.

    Vitamin C may also increase the glomerular filtration rate and increase the excretion of uric acid by reducing glomerular capillary ischemia and dilating glomerular arteries.

    3.
    In addition, Vitamin C is a powerful antioxidant, which can reduce the damage of free radicals to cells, thereby reducing the formation of uric acid and reducing 24h uric acid [9].

    4.
    Recent studies have also shown that ascorbic acid plays an important role in reducing uric acid-induced inflammation by inhibiting the activation of NLRP3 inflammasomes [10-11].

    04 What fruits to eat can supplement vitamin C.
    Under normal circumstances, most people can get enough vitamin C from their daily diet without taking additional vitamin C supplements.

    Which foods contain more vitamin C? You may try the following fruits.

    First place: wild jujube.

    The vitamin C contained in wild jujube is as high as 86.
    3% in the human body, which is the best among all fruits.
    Therefore, wild jujube has become the first place in the vitamin C fruit list.

    No.
    2: Blackcurrant.

    The vitamin C content in the same number of blackcurrants is 4 times that of oranges.

    No.
    3: Strawberry.

    Strawberries are rich in malic acid, citric acid, carotene and trace elements.
    Among them, the vitamin content is 7-10 times higher than that of apples and grapes.

    No.
    4: Kiwi.

    Kiwifruit is rich in kiwifruit alkali, proteolytic enzymes, multiple trace elements and 17 kinds of amino acids required by the human body.
    Kiwifruit contains extremely high content of vitamin C.
    One kiwifruit can provide a person with vitamin C for a day.
    content.

    No.
    5: Loquat.

    Ripe loquat contains a variety of fructose, vitamins and trace elements.
    Among them, the content of carotene is ranked third among various fruits.
    The pulp of loquat also has the effects of moisturizing the lungs, relieving cough, and quenching thirst.

    The vitamin C content in loquat can whiten and nourish the skin and lighten spots.

    No.
    6: Oranges.

    The specific weight of an orange cannot be engraved.
    According to the composition analysis, every 100g orange contains 28mg of vitamin C, but the vitamin C content in oranges is lower than that in loquats.

    No.
    7: Oranges. Containing a variety of organic acids and vitamins can help the human body to regulate the body's metabolism, and vitamin C can also have a certain anti-cancer effect.

    No.
    8: Cherry.

    Compared to vitamin C, cherries actually contain more iron, and the content of vitamin A and carotene are many times that of grapes, apples and oranges.

    No.
    9: Lemon.

    Lemon is rich in citric acid and vitamin C, which can treat symptoms such as bronchitis, whooping cough, loss of appetite, vitamin deficiency, heatstroke and polydipsia.
    The vitamin C contained in lemon makes lemon the nemesis of scurvy.

    10th place: Lychee.

    Lychees are rich in glucose, sucrose, protein, fat and various vitamins A, B, and C, which are very beneficial to the human body.

    05Summary Vitamin C has a positive effect on purine metabolism and helps to reduce the level of uric acid, thereby reducing the risk of monosodium urate crystals depositing in joint structures and soft tissues.

    However, these studies are limited due to the short observation time.

    In order to reach a final conclusion, more patients need to be followed up for a long time, and long-term intervention studies are needed.

    In addition, excessive intake of vitamin C can damage the blood system, nervous system, kidney system, and digestive system.

    Therefore, it is recommended that everyone consume vitamin C in moderation.

    At present, the most reasonable way to treat gout is to recommend a balanced diet, eat more vegetables, fruits and grains, and eat less meat and meat products.

    In addition, it is necessary to maintain proper weight and physical activity, while quitting smoking is also very important.

    References: [1] Chen Yuhang, Zhuang Yu, Wang Zhiwen, et al.
    Clinical observation of a new method of lowering uric acid in the treatment of acute gouty arthritis[J].
    Qingdao Medical Health, 2017 49 (5): 321-323.
    [2] Gonzalez EB.
    An update on the pathology and c1inicaI management of gouty arthritis[J].
    Clin Rheumatol, 2012, 31 (1): 13-21.
    [3]Li L,Zhang Y,Zeng C.
    Update on the epidemiology, genetics, and therapeutic options of hyperuricemia.
    Am JT ransl.
    Res,2020, 12, 3167-3181.
    [4]oman YM,Daniel K.
    Inouye College of Pharmacy Scripts: Perspectives on the Epidemiology of Gout and Hyperuricemia.
    Hawaii J.
    Med.
    Public Health,2019, 78, 71–76.
    [5]Juraschek SP,Miller ER, Gelber AC.
    Effect of oral vitamin C supplementation on serum uric acid: a meta-analysis of randomized controIled trials[J].
    Artbritis Care Res (Hoboken ), 2011, 63 (9): 1295-1306.
    [6] Ma Ling, Wang Li, Zhou Yong, et al.
    The correlation between serum vitamin A, C, E levels and uric acid levels[J] Chinese Journal of Gerontology, 2013, 33(12): 2742-2744.
    [7] Jia Shaodan, Wang Yangang, etc.
    Research on the relationship between different uric acid concentrations and oxidative stress and endothelial injury indexes [J].
    Chinese Journal of Internal Medicine, 2008, 47(8): 38-41.
    [8] Ma Qiaolan, Jiang Zhuoqin, Deng Liang.
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