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▎Editor of WuXi AppTec's content team In recent years, vitamin D has gradually become a research hotspot
.
Some emerging evidence suggests that vitamin D has a potential role in the prevention and treatment of cancer, especially tumors of the digestive system
.
Recently, a research led by scholars from Harvard University School of Public Health, Dana-Farber Cancer Institute, Yale Cancer Center and other institutions participated and published in "Gastroenterology" (Gastroenterology) to explore the relationship between vitamin D and early onset.
The relationship between the risk of rectal cancer (Early-Onset Colorectal Cancer)
.
Studies have found that higher intake of vitamin D (mainly derived from food, such as milk, fish, eggs, etc.
) is associated with a reduced risk of early-onset colorectal cancer and colorectal precancerous lesions
.
Screenshot source: Gastroenterology epidemiological data shows that although the overall incidence of colorectal cancer is declining, the incidence of young people is increasing
.
Previous evidence suggests that there is an association between vitamin D intake and the risk of death from colorectal cancer
.
The Dana-Farber Cancer Institute press release mentioned that this study is "the first observation that vitamin D intake is associated with a decreased risk of early-onset colorectal cancer
.
"
The study included 94,205 women aged 25 to 42 years
.
Researchers conduct statistics on subjects every two years, and record their usual diet, life>
.
And record in the follow-up questionnaire whether the subject has undergone colonoscopy or sigmoidoscopy
.
The primary endpoint is the risk of subjects diagnosed with early-onset colorectal cancer or colorectal precancerous lesions before the age of 50
.
The study found that between 1991 and 2015, 111 cases of early-onset colorectal cancer and 3317 cases of colorectal polyps occurred
.
Further analysis showed that, compared with daily intake of vitamin D<300 IU, daily intake of vitamin D≥450 IU was associated with a 51% reduction in the risk of colorectal cancer (HR=0.
49, P=0.
01), with every increase in vitamin D 400 IU/day, the risk of colorectal cancer is reduced by 54% (HR=0.
46)
.
400-450 IU of vitamin D per day is approximately equivalent to eating 100g salmon, 300g sardines, and 750g yogurt
.
If the same amount of vitamin D (400 IU) is consumed daily, dietary intake of vitamin D is more associated with a reduction in disease risk than supplements: the former is associated with a 66% reduction in the risk of colorectal cancer (HR= 0.
34).
The latter is related to a 23% reduction in the risk of colorectal cancer (HR=0.
77)
.
A similar relationship was also found in precancerous lesions of the colorectal
.
For every 400 IU/day increase in vitamin D, the risk of colorectal adenomas is reduced by 24% (HR=0.
76), and the risk of serrated polyps is reduced by 15% (HR 0.
85)
.
Interestingly, the researchers did not find a significant association between total vitamin D intake and the risk of colorectal cancer diagnosed after the age of 50
.
The researchers said that it is necessary to conduct further studies on larger samples to determine whether vitamin D can reduce the risk of early-onset colorectal cancer
.
"Our results further support that vitamin D may be important for the health of young people and the prevention of colorectal cancer
.
" said the senior author of the study, Dr.
Kimmie Ng from the Dana-Farber Cancer Institute
.
The association between vitamin D and colorectal cancer has previously been published in top journals
.
However, these findings are not entirely consistent
.
A secondary analysis of the VITAL study published in JAMA Network Open, a sub-issue of the Journal of the American Medical Association, data from trials of more than 25,000 people aged 50 years or older showed that taking vitamin D and developing advanced (metastatic or lethal) cancers reduce the overall risk of cancer 17% is related, and people with normal weight (BMI<25) benefit more significantly
.
Two studies published in the Journal of the American Medical Association (JAMA) in 2019 explored the role of vitamin D in the treatment of colorectal cancer
.
In the SUNSHINE study, data from 139 patients with advanced or metastatic colorectal cancer showed that high-dose vitamin D (4000 IU/day) increased the risk of colorectal cancer progression compared to the standard dose of vitamin D supplementation (400 IU/day) Significantly reduced by 36%, the median progression-free survival (PFS) of the two groups was 13.
0 months and 11.
0 months, respectively
.
In the AMATERASU study, data from 417 patients with stage 1-3 gastrointestinal cancer (48% of colorectal cancers) showed that after tumor resection, patients who received 2000 IU/day vitamin D oral capsules had a 5-year recurrence-free survival rate.
It was slightly higher than the placebo group (77% vs 69%), the vitamin D group reduced the risk of recurrence and death by 24%, but it did not reach a statistical difference
.
In the editorial published in the same journal of JAMA at that time, experts believed that overall, the anti-tumor effect of high-dose vitamin D initially shown in the research, especially the effect in gastrointestinal tumors, deserves further study
.
Image source: 123RF, whether it is for the prevention of colorectal cancer in people of different ages, or the potential of vitamin D in treatment, we look forward to the accumulation of more research evidence to reveal the role of vitamin D in the occurrence and development of colorectal cancer
.
Related reading Can vitamin D prevent cancer? The Harvard study updated positive evidence that it is more effective for these people.
JAMA: Vitamin D should not be supplemented! To prevent osteoporosis, the more you are careful, the more loose you are.
.
.
JAMA: To prevent diseases, vitamin D supplements have repeatedly failed in clinical trials? Vitamin D is good for longevity? West China Hospital team BMJ published two JAMAs on big data of 70,000 people on the same day: Can Vitamin D really cure cancer? Source of title picture: 123RF reference materials[1] Kim, H.
, et al.
, (2021).
Total vitamin D intake and risks of early-onset colorectal cancer and precursors.
Gastroenterology, DOI: 10.
1053/j.
gastro.
2021.
07.
002[2] Vitamin D may protect against young-onset colorectal cancer.
Retrieved 17, 2021, FROM https://medicalxpress.
com/news/2021-08-vitamin-d-young-onset-colorectal-cancer.
html[3 ] Food Sources of Vitamin D.
retrieved 2019, from https:// The content team of Mingkangde focuses on introducing the global biomedical health research progress
.
This article is for the purpose of information exchange only.
The opinions expressed in the article do not represent the position of WuXi AppTec, nor does it mean that WuXi AppTec supports or opposes the views in the article
.
This article is not a treatment recommendation either
.
If you need guidance on the treatment plan, please go to a regular hospital for treatment
.
.
Some emerging evidence suggests that vitamin D has a potential role in the prevention and treatment of cancer, especially tumors of the digestive system
.
Recently, a research led by scholars from Harvard University School of Public Health, Dana-Farber Cancer Institute, Yale Cancer Center and other institutions participated and published in "Gastroenterology" (Gastroenterology) to explore the relationship between vitamin D and early onset.
The relationship between the risk of rectal cancer (Early-Onset Colorectal Cancer)
.
Studies have found that higher intake of vitamin D (mainly derived from food, such as milk, fish, eggs, etc.
) is associated with a reduced risk of early-onset colorectal cancer and colorectal precancerous lesions
.
Screenshot source: Gastroenterology epidemiological data shows that although the overall incidence of colorectal cancer is declining, the incidence of young people is increasing
.
Previous evidence suggests that there is an association between vitamin D intake and the risk of death from colorectal cancer
.
The Dana-Farber Cancer Institute press release mentioned that this study is "the first observation that vitamin D intake is associated with a decreased risk of early-onset colorectal cancer
.
"
The study included 94,205 women aged 25 to 42 years
.
Researchers conduct statistics on subjects every two years, and record their usual diet, life>
.
And record in the follow-up questionnaire whether the subject has undergone colonoscopy or sigmoidoscopy
.
The primary endpoint is the risk of subjects diagnosed with early-onset colorectal cancer or colorectal precancerous lesions before the age of 50
.
The study found that between 1991 and 2015, 111 cases of early-onset colorectal cancer and 3317 cases of colorectal polyps occurred
.
Further analysis showed that, compared with daily intake of vitamin D<300 IU, daily intake of vitamin D≥450 IU was associated with a 51% reduction in the risk of colorectal cancer (HR=0.
49, P=0.
01), with every increase in vitamin D 400 IU/day, the risk of colorectal cancer is reduced by 54% (HR=0.
46)
.
400-450 IU of vitamin D per day is approximately equivalent to eating 100g salmon, 300g sardines, and 750g yogurt
.
If the same amount of vitamin D (400 IU) is consumed daily, dietary intake of vitamin D is more associated with a reduction in disease risk than supplements: the former is associated with a 66% reduction in the risk of colorectal cancer (HR= 0.
34).
The latter is related to a 23% reduction in the risk of colorectal cancer (HR=0.
77)
.
A similar relationship was also found in precancerous lesions of the colorectal
.
For every 400 IU/day increase in vitamin D, the risk of colorectal adenomas is reduced by 24% (HR=0.
76), and the risk of serrated polyps is reduced by 15% (HR 0.
85)
.
Interestingly, the researchers did not find a significant association between total vitamin D intake and the risk of colorectal cancer diagnosed after the age of 50
.
The researchers said that it is necessary to conduct further studies on larger samples to determine whether vitamin D can reduce the risk of early-onset colorectal cancer
.
"Our results further support that vitamin D may be important for the health of young people and the prevention of colorectal cancer
.
" said the senior author of the study, Dr.
Kimmie Ng from the Dana-Farber Cancer Institute
.
The association between vitamin D and colorectal cancer has previously been published in top journals
.
However, these findings are not entirely consistent
.
A secondary analysis of the VITAL study published in JAMA Network Open, a sub-issue of the Journal of the American Medical Association, data from trials of more than 25,000 people aged 50 years or older showed that taking vitamin D and developing advanced (metastatic or lethal) cancers reduce the overall risk of cancer 17% is related, and people with normal weight (BMI<25) benefit more significantly
.
Two studies published in the Journal of the American Medical Association (JAMA) in 2019 explored the role of vitamin D in the treatment of colorectal cancer
.
In the SUNSHINE study, data from 139 patients with advanced or metastatic colorectal cancer showed that high-dose vitamin D (4000 IU/day) increased the risk of colorectal cancer progression compared to the standard dose of vitamin D supplementation (400 IU/day) Significantly reduced by 36%, the median progression-free survival (PFS) of the two groups was 13.
0 months and 11.
0 months, respectively
.
In the AMATERASU study, data from 417 patients with stage 1-3 gastrointestinal cancer (48% of colorectal cancers) showed that after tumor resection, patients who received 2000 IU/day vitamin D oral capsules had a 5-year recurrence-free survival rate.
It was slightly higher than the placebo group (77% vs 69%), the vitamin D group reduced the risk of recurrence and death by 24%, but it did not reach a statistical difference
.
In the editorial published in the same journal of JAMA at that time, experts believed that overall, the anti-tumor effect of high-dose vitamin D initially shown in the research, especially the effect in gastrointestinal tumors, deserves further study
.
Image source: 123RF, whether it is for the prevention of colorectal cancer in people of different ages, or the potential of vitamin D in treatment, we look forward to the accumulation of more research evidence to reveal the role of vitamin D in the occurrence and development of colorectal cancer
.
Related reading Can vitamin D prevent cancer? The Harvard study updated positive evidence that it is more effective for these people.
JAMA: Vitamin D should not be supplemented! To prevent osteoporosis, the more you are careful, the more loose you are.
.
.
JAMA: To prevent diseases, vitamin D supplements have repeatedly failed in clinical trials? Vitamin D is good for longevity? West China Hospital team BMJ published two JAMAs on big data of 70,000 people on the same day: Can Vitamin D really cure cancer? Source of title picture: 123RF reference materials[1] Kim, H.
, et al.
, (2021).
Total vitamin D intake and risks of early-onset colorectal cancer and precursors.
Gastroenterology, DOI: 10.
1053/j.
gastro.
2021.
07.
002[2] Vitamin D may protect against young-onset colorectal cancer.
Retrieved 17, 2021, FROM https://medicalxpress.
com/news/2021-08-vitamin-d-young-onset-colorectal-cancer.
html[3 ] Food Sources of Vitamin D.
retrieved 2019, from https:// The content team of Mingkangde focuses on introducing the global biomedical health research progress
.
This article is for the purpose of information exchange only.
The opinions expressed in the article do not represent the position of WuXi AppTec, nor does it mean that WuXi AppTec supports or opposes the views in the article
.
This article is not a treatment recommendation either
.
If you need guidance on the treatment plan, please go to a regular hospital for treatment
.