Vitamin E and selenium supplementation do not prevent dementia in asymptomatic elderly men

According to a new study published in JAMA neurology, vitamin E and selenium supplementation alone or in combination could not prevent dementia in asymptomatic elderly men Since oxidative stress is related to dementia signaling pathway, there has been an interest in using antioxidants to treat cognitive impairment and dementia in recent years This clinical trial of using vitamin E and selenium to prevent Alzheimer's disease (http:// (predvise) recruited 7540 elderly men at the beginning, supplemented with related substances for up to 5 years, and finally 3786 men agreed to receive further observation They accepted the following test methods: vitamin E supplement, selenium supplement, both supplement, or placebo According to the study author, Dr Richard J kryscio, University of Kentucky, the results showed that there was no difference in the prevalence of Alzheimer's disease among the four groups (325 / 7338, 4.4%) The drawback of this study is that about half of the participants were lost during the transition from randomized clinical trials to cohort trials At the same time, the author believes that the publicity of side effects of these supplements also has a negative impact The authors of the study said vitamin E and selenium supplementation did not prevent dementia and were therefore not recommended as preventive drugs (http:// Of course, this conclusion is a little thin, because this research is not perfect, including only male, too short time, dose problems and the methodological limitations of reporting the incidence rate of patients' families